Browsing by Author "Boltze, Johannes"
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- Editorial: Advanced (gene and cell) therapies for central nervous system applicationsPublication . Mendonça, Liliana; Webster, Christopher; Boltze, Johannes; Nóbrega, ClévioAdvanced therapies as defined by the European Medicines Agency (EMA) comprises strategies involving gene therapy, cell therapy, and tissue engineering. Overall, these strategies offer a wide range of possibilities to treat and cure diseases, including those affecting the central nervous system (CNS). In this line, Advanced (Gene and Cell) Therapies for Central Nervous System Applications Research Topic was intended to provide a platform for researchers to publish their findings, contributing to the continuous advance of this research area. Nine papers were accepted and published in this Research Topic, from which four described original research data, two papers were reviews and two mini reviews, and one paper focused on hypothesis and theory. In the paper Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques (Arotcarena et al.), presented new data on the biodistribution and CNS transduction efficiencies after lumbar intrathecal bolus delivery of identical doses of either AAV-PH.B:CAG-EGFP or AAV-PHP.eB:CAG-EGFP in rhesus macaque monkeys.
- Editorial: Global excellence in gene and cell therapy: EuropePublication . Mendonça, Liliana; Boltze, Johannes; Nóbrega, ClévioGene therapy changes protein expression in cells through the insertion of genes and/or gene expression-modulating tools, including gene editing. It can be used in the treatment of a variety of diseases, including genetic disorders, by reducing the levels of disease-causing proteins or by increasing the expression of missing or protective proteins. Cell therapy by the transplantation of cells or tissues aims to repair, regenerate, or replace a specific cell population and/or tissue to reestablish the physiological function performed by the cells/tissues to replace. In this line, Global Excellence in the Gene and Cell Therapy: Europe Research Topic was launched with the goal of highlighting the latest advancements in Gene and Cell Therapy field and reflecting on the future challenges faced by researchers across Europe. Six papers were accepted and published for this Research Topic, from which three describe original research data, one is a systematic review, one is a narrative paper, and the last one is a perspective article.