Editorial: Global excellence in gene and cell therapy: Europe

Mendonça, Liliana; Boltze, Johannes; Nóbrega, Clévio

http://hdl.handle.net/10400.1/19817

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Authors

Mendonça, Liliana

Boltze, Johannes

Nóbrega, Clévio

Abstract(s)

Gene therapy changes protein expression in cells through the insertion of genes and/or gene expression-modulating tools, including gene editing. It can be used in the treatment of a variety of diseases, including genetic disorders, by reducing the levels of disease-causing proteins or by increasing the expression of missing or protective proteins. Cell therapy by the transplantation of cells or tissues aims to repair, regenerate, or replace a specific cell population and/or tissue to reestablish the physiological function performed by the cells/tissues to replace. In this line, Global Excellence in the Gene and Cell Therapy: Europe Research Topic was launched with the goal of highlighting the latest advancements in Gene and Cell Therapy field and reflecting on the future challenges faced by researchers across Europe. Six papers were accepted and published for this Research Topic, from which three describe original research data, one is a systematic review, one is a narrative paper, and the last one is a perspective article.

Keywords

Regulatory landscape for ATMPs AAVs-mediated gene delivery Riboswitch-regulated AAVs Rregulatory T cells production and regulation AAV8-mediated gene therapy combined with chemotherapy