Percorrer por tipo de recurso "editorial"
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- Difficult diagnosis of a foreign body inhalation in a COPD patientPublication . Barros, Pedro Pereira; Santos, Bruno dos; Brito, Ulisses61-Year-old male, former smoker, medical history of chronic obstructive pulmonary disease GOLD 3B. In the outpatient follow-up, the patient had complaints of stridor, dysphonia, and precordial oppression, while denying any choking episode. After otorhinolaryngology observation, no alterations were seen in the laryngoscopy. In the next clinical evaluation, there was a worsening of the patient’s dysphonia and dyspnea.
- EditorialPublication . Power, Deborah; Sheridan, Mark; Dores, Robert M.In a globally changing climate and with the alarming loss of biodiversity Comparative Endocrinology becomes ever more relevant as a scientific discipline. The comparative endocrinologist continues to be at the frontline of scientific endeavour trying to understand the myriad complexities of life forms on earth by looking at the regulatory factors that underpin key events in an organisms’ life and ensure maintenance of homeostasis and species survival.
- Editorial: (un)healthy lifestyles, aging, and type 2 diabetesPublication . Duarte-Mendes, Pedro; Fernanda M. Silva; Teixeira, Ana M.Recent estimates from the IDF Diabetes Atlas indicate that diabetes affects 589 million adults worldwide in 2024, with type 2 diabetes (T2D) accounting for more than 90% of cases (International Diabetes Federation, 2025). This number is projected to reach 853 million by 2050. Age is an important risk factor for T2D, with estimates indicating that one in four adults with the disease (158 million) are over 65 years old. Poor lifestyle factors, such as lack of exercise, sedentary behavior, and poor diet, are important underlying factors in the development of obesity and insulin resistance, leading to T2D and cardiovascular disease (Lu et al., 2024; Bowden Davies et al., 2018). On the other hand, effective interventions, such as regular exercise and a healthy diet, have been recommended to improve glucose metabolism in both diabetic and non-diabetic individuals (Silva et al., 2024; Syeda et al., 2023; Kim and Kwon, 2024). In addition to engaging in regular exercise, studies have demonstrated the benefits of interrupting sitting time with regular bouts of movement (Syeda et al., 2023). Given the high prevalence of T2D, mainly in the middle-aged and elderly population, it is important to investigate the impact of (un)healthy lifestyles on metabolic markers and to create a set of strategies to prevent or control T2D and its related complications. This Research Topic, Editorial: (Un)healthy lifestyles, Aging, and Type 2 Diabetes, addresses these questions through nine complementary contributions.
- Editorial: advances in senior tourism researchPublication . Santos, José António C.; Santos, Margarida CustódioThis editorial sought to highlight the relevance and potential of the senior tourism market; discuss shortcomings related to current aged-based segmentation approaches; and highlight the contributions made by each of the nine papers of this Special Issue on Senior Tourism. This editorial updated relevant data related to the senior tourism market, emphasizing todays characteristics of this segment. It points also directions for future research and concludes that this special issue makes a significant contribution to senior tourism research.
- Editorial: advancing cancer therapy: innovative strategies targeting immune evasion and metabolic modulationPublication . Teotónio Fernandes, Mónica Alexandra; De Sousa-Coelho, Ana Luísa; Méndez-Lucas, AndrésCancer remains one of the leading causes of death worldwide, with both incidence and mortality continuing to rise despite advances in diagnosis and treatment (1). While early-stage cancers often respond to conventional therapies, advanced and recurrent tumors frequently develop resistance, limiting long-term therapeutic efficacy (2).Two fundamental hallmarks of cancer, immune evasion and metabolic reprogramming, enable tumors to thrive in hostile microenvironments (3, 4). Although immunotherapies have revolutionized cancer care, a significant proportion of patients either fail to respond or acquire resistance over time (5). In parallel, altered tumor metabolism is increasingly recognized as a promising therapeutic target, particularly for enhancing responses to immunotherapy (7).This Research Topic highlights recent advances that move beyond traditional treatment. Collectively, the nine featured articles provide valuable insights into the interplay between immunity and metabolism in cancer, exploring strategies to overcome therapeutic resistance and improve clinical outcomes across diverse cancer types.
- Editorial: Endocrine disruption in marine species: unraveling pollution and climate change effectsPublication . Bertucci, Juan Ignacio; Blanco, Ayelén Melisa; Estêvão, Maria Dulce da Mota Antunes de OliveiraEndocrine disruption in marine species has emerged as a significant concern in environmental endocrinology, particularly in the context of escalating anthropogenic pressures. Persistent pollutants, including microplastics, heavy metals, and agrochemical residues, alongside climate-induced stressors like ocean warming and acidification, are now recognized as potent modulators of endocrine function in aquatic organisms. These stressors compromise critical physiological and behavioral processes, with potential implications for individual fitness, population viability, and ecosystem stability. The Research Topic Endocrine disruption in marine species: unraveling pollution and climate change effects brings together a multidisciplinary set of contributions that examine the mechanistic underpinnings, organismal impacts, and ecological implications of endocrine disruption across marine taxa. This editorial synthesizes the key findings, contextualizes them within the broader scientific discourse, and highlights knowledge gaps and future research directions.
- Editorial: Endocrine regulation and physiological adaptation of stress response in aquatic organismsPublication . Li, Yiming; Li, Yi-Feng; Campinho, Marco António; Fuentes, JuanOrganismal growth is a complex, genetically regulated process that integrates various physiological signaling pathways, where endocrine regulation is pivotal. In fully developed animals, endocrine regulation plays a central role in maintaining homeostasis and adapting to changing environmental and biological conditions. In aquatic organisms, environmental stressors such as environmental temperature, hypoxia, salinity changes, and exposure to pollutants can disrupt homeostasis, leading to physiological, molecular, and behavioral responses. Understanding the molecular and cellular mechanisms of endocrine regulation and physiological adaptation in response to environmental stresses is crucial, significantly impacting aquatic ecosystems. The main objective of this Research Topic was to explore and discuss these mechanisms, providing valuable insights into aquatic animal biology and adaptation.
- Editorial: Gene Silencing and Editing Strategies for Neurodegenerative DiseasesPublication . Nobrega, Clevio; Alves, Sandro
- Editorial: Global excellence in gene and cell therapy: EuropePublication . Mendonça, Liliana; Boltze, Johannes; Nóbrega, ClévioGene therapy changes protein expression in cells through the insertion of genes and/or gene expression-modulating tools, including gene editing. It can be used in the treatment of a variety of diseases, including genetic disorders, by reducing the levels of disease-causing proteins or by increasing the expression of missing or protective proteins. Cell therapy by the transplantation of cells or tissues aims to repair, regenerate, or replace a specific cell population and/or tissue to reestablish the physiological function performed by the cells/tissues to replace. In this line, Global Excellence in the Gene and Cell Therapy: Europe Research Topic was launched with the goal of highlighting the latest advancements in Gene and Cell Therapy field and reflecting on the future challenges faced by researchers across Europe. Six papers were accepted and published for this Research Topic, from which three describe original research data, one is a systematic review, one is a narrative paper, and the last one is a perspective article.
- Editorial: Manipulation of plant architecture for crop productionPublication . Hilioti, Zoe; Panagiotis, Kalaitzis; Merkouropoulos, Georgios; Antunes, Maria DulcePlant architecture, encompassing the spatial arrangement and morphological characteristics of plant organs, plays a crucial role in agricultural productivity. This Research Topic presents current research and review on the manipulation of plant architecture in major crops, highlighting key findings from genome-wide association studies (GWAS), quantitative trait loci (QTL) mapping, Simple Sequence Repeat (SSR) markers, and genetic manipulation efforts.
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