Percorrer por autor "Costa, Luís"
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- Anthracyclines versus no anthracyclines in the neoadjuvant strategy for HER2+ breast cancer: real-world evidencePublication . Pinho, Inês Soares de; Luz, Paulo; Alves, Lucy; Brás, Raquel Lopes; Patel, Vanessa; Martins, Miguel Esperança; Gonçalves, Lisa; Freitas, Ritas; Simão, Diana; Roldán Galnares, Maria; Fernandes, Isabel; Criado, Silvia Artacho; Gamez Casado, Salvador; Baena Cañada, Jose; Vega, Isabel M. Saffie; Costa, João G.; Fernandes, Ana S.; Sousa, Rita Teixeira de; Costa, LuísDeescalation strategies omitting anthracyclines (AC) have been explored in early human epidermal growth factor receptor 2-positive breast cancer (HER2+ EBC), showing similar efcacy regarding pathological complete response (pCR) and long-term outcomes as AC-containing regimens. The standard treatment for this tumor subtype is based on chemotherapy and dual HER2 blockade with trastuzumab and pertuzumab, with AC-containing regimens remaining a frequent option for these patients, even in non-high-risk cases. The primary aim of this study was to assess and compare the efectiveness of neoadjuvant regimens with and without AC used in the treatment of HER2+ EBC in the clinical practice according to the pCR achieved with each.
- Estimating harvested rainwater at greenhouses in south Portugal aquifer Campina de Faro for potential infiltration in Managed Aquifer RechargePublication . Costa, Luís; Monteiro, José Paulo; Leitão, Teresa; Lobo-Ferreira, João Paulo; Oliveira, Manuel; Carvalho, José Martins de; Carvalho, Tiago Martins de; Agostinho, RuiThe Campina de Faro (CF) aquifer system, located on the south coast of Portugal, is an important source of groundwater, mostly used for agriculture purposes. In some areas, this multi-layered aquifer is contaminated with high concentration of nitrates, possibly arising from excessive usage of fertilizers, reaching to values as high as 300 mg/L.
- Integration of managed aquifer recharge into the water supply system in the Algarve region, PortugalPublication . Standen, Kathleen; Costa, Luís; Hugman, Rui; Monteiro, José PauloThe Algarve region of Portugal is experiencing severe water scarcity with existing water supplies insufficient to meet demand, with limited resilience to drought. Managed aquifer recharge (MAR) can provide intermediate storage and bridge the gap between water availability and demand, with success depending on the water available and the aquifer capacity to accept and store the water. We present the results of a regional study quantifying both these aspects to estimate the regional potential for MAR. Our results demonstrate that MAR can comprise 10% of the total water demand of the region (24 Mm3/yr) using water that is not otherwise captured, with quality that meets the requirements of the Groundwater Directive. MAR can replace 15 Mm3/yr of surface water used in the public irrigation perimeters and 9 Mm3/yr can be used to develop and maintain a strategic groundwater resource in the aquifers of the Central Algarve. Although climate change is predicted to result in an 8–13% decrease in MAR recharge, this can be addressed by incrementally increasing MAR design capacity. MAR has similar water resource benefits to the planned major infrastructure projects (desalination and River Guadiana abstraction), with reduced environmental impacts and lower costs than almost all feasible alternatives. We conclude that MAR is an important measure to increase water supply security and drought resilience in the Algarve region.
- Integration of managed aquifer recharge into the water supply system in the Algarve region, PortugalPublication . Standen, Kathleen; Costa, Luís; Hugman, Rui; Monteiro, José PauloThe Algarve region of Portugal is experiencing severe water scarcity with existing water supplies insufficient to meet demand, with limited resilience to drought. Managed aquifer recharge (MAR) can provide intermediate storage and bridge the gap between water availability and demand, with success depending on the water available and the aquifer capacity to accept and store the water. We present the results of a regional study quantifying both these aspects to estimate the regional potential for MAR. Our results demonstrate that MAR can comprise 10% of the total water demand of the region (24 Mm(3)/yr) using water that is not otherwise captured, with quality that meets the requirements of the Groundwater Directive. MAR can replace 15 Mm(3)/yr of surface water used in the public irrigation perimeters and 9 Mm(3)/yr can be used to develop and maintain a strategic groundwater resource in the aquifers of the Central Algarve. Although climate change is predicted to result in an 8-13% decrease in MAR recharge, this can be addressed by incrementally increasing MAR design capacity. MAR has similar water resource benefits to the planned major infrastructure projects (desalination and River Guadiana abstraction), with reduced environmental impacts and lower costs than almost all feasible alternatives. We conclude that MAR is an important measure to increase water supply security and drought resilience in the Algarve region.
- Modelling contributions of the local and regional groundwater flow of managed aquifer recharge activities at Querença-Silves Aquifer SystemPublication . Costa, Luís; Monteiro, José Paulo; Oliveira, Manuel; Mota, Rogério; Lobo-Ferreira, João Paulo; Carvalho, José Martins de; Carvalho, Tiago Martins de; Agostinho, Rui; Hugman, RuiThe Querença-Silves (QS) aquifer system is one of the most important natural groundwater reservoirs in the Algarve region of southern Portugal. With a surface area of 324 km2, this karst aquifer system is the main source of supply for irrigation as well as an important source of water for the urban supply.
- A randomized controlled trial assessing the release of circulating tumor and mesenchymal cells in no-touch radical nephrectomyPublication . Leitão, Tito Palmela; Corredeira, Patrícia; Rodrigues, Carolina; Piairo, Paulina; Miranda, Miguel; Martins Cavaco, Ana Cláudia; Kucharczak, Sandra; Antunes, Marília; Peixoto, Sara; Reis, José Palma dos; Lopes, Tomé; Diéguez, Lorena; Costa, LuísAbstract: Background: Circulating tumor cells (CTCs) may be the missing renal cell carcinoma (RCC) biomarker. No-touch (NT) resection has shown benefit in several tumors. Methods: A randomized controlled trial comparing CTC and circulating mesenchymal cell (CMC) release in no-touch (NT) vs. conventional (C) laparoscopic RN. Blood samples were collected at operation room arrival (S0), specimen extraction (S1), postoperative D1, and D30. CTCs were isolated and analyzed using RUBYchip™. Results: Thirty-four patients were included. No significant differences were found between groups in CTC and CMC counts, count variations between time points, complications, and survival. The total circulating cell detection rates in the NT, C, and overall RCC groups were 58.3%, 80.0%, and 70.4% at S0; 41.6%, 86.7%, and 66.7% at S1; 50.0%, 64.3%, and 60.0% at D1; and 54.5%, 42.9%, and 44.0% at D30, respectively. A progressive decrease in CMCs was observed in the C group after surgery, especially at D1 (4.78 to 1.64 CMCs/7.5 mL blood, p = 0.035). Healthy controls had no circulating cells; however, high CMC counts were found in chronic inflammation controls and oncocytoma patients, with no significant difference from RCC patients (p = 0.460). Conclusions: NT RN did not reduce circulating cell release nor improve survival compared to C RN.