Percorrer por autor "Nguyen, Nga"
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- Design and synthesis of novel quinic acid derivatives: in vitro cytotoxicity and anticancer effect on glioblastomaPublication . Murugesan, Akshaya; Holmstedt, Suvi; Brown, Kenna C.; Koivuporras, Alisa; Macedo, Ana S.; Nguyen, Nga; Fonte, Pedro; Rijo, Patricia; Yli-Harja, Olli; Candeias, Nuno R.; Kandhavelu, MeenakshisundaramAim: Quinic acid (QA) is a cyclic polyol exhibiting anticancer properties on several cancers. However, potential role of QA-derivatives against glioblastoma is not well established. Methodology & results: Sixteen novel QA-derivatives and QA-16 encapsulated poly (lactic-co-glycolic acid) nanoparticles (QA-16-NPs) were screened for their anti-glioblastoma effect using standard cell and molecular biology methods. Presence of a tertiary hydroxy and silylether groups in the lead compound were identified for the antitumor activity. QA-16 have 90% inhibition with the IC50 of 10.66 mu M and 28.22 mu M for LN229 and SNB19, respectively. The induction of apoptosis is faster with the increased fold change of caspase 3/7 and reactive oxygen species. Conclusion: QA-16 and QA-16-NPs shows similar cytotoxicity effect, providing opportunity to use QA-16 as a potential chemotherapeutic agent.
- Tropical field stations yield high conservation return on investmentPublication . Eppley, Timothy M.; Reuter, Kim E.; Sefczek, Timothy M.; Tinsman, Jen; Santini, Luca; Hoeks, Selwyn; Andriantsaralaza, Seheno; Shanee, Sam; Fiore, Anthony Di; Setchell, Joanna M.; Strier, Karen B.; Abanyam, Peter A.; Mutalib, Aini Hasanah Abd; Abwe, Ekwoge; Ahmed, Tanvir; Ancrenaz, Marc; Andriantsimanarilafy, Raphali R.; Ang, Andie; Aureli, Filippo; Barrett, Louise; Beehner, Jacinta C.; Benítez, Marcela E.; Bezerra, Bruna M.; Bicca‐Marques, Júlio César; Bikaba, Dominique; Bitariho, Robert; Boesch, Christophe; Bolt, Laura M.; Boonratana, Ramesh; Butynski, Thomas M.; Canale, Gustavo R.; Chapman, Colin A.; Carvalho, Susana; Chetry, Dilip; Cheyne, Susan M.; Cords, Marina; Cornejo, Fanny M.; Cortés‐Ortiz, Liliana; Coudrat, Camille N. Z.; Crofoot, Margaret C.; Cronin, Drew T.; Dadjo, Alvine; Dakpogan, S. Chrystelle; Danquah, Emmanuel; Davenport, Tim R. B.; Jong, Yvonne A. de; Torre, Stella de la; Dempsey, Andrea; Dimalibot, Judeline C.; Dolch, Rainer; Donati, Giuseppe; Estrada, Alejandro; Farassi, Rassina A.; Fashing, Peter J.; Fernandez‐Duque, Eduardo; Silva, Maria J. Ferreira da; Fischer, Julia; Flores‐Negrón, César F.; Fruth, Barbara; Neba, Terence Fuh; Gamalo, Lief Erikson; Ganzhorn, Jörg U.; Garber, Paul A.; Gnanaolivu, Smitha D.; Gonder, Mary Katherine; Bi, Sery Ernest Gonedelé; Goossens, Benoit; Gordo, Marcelo; Guayasamin, Juan M.; Guzmán‐Caro, Diana C.; Halloran, Andrew R.; Hartel, Jessica A.; Heymann, Eckhard W.; Hill, Russell A.; Hockings, Kimberley J.; Hohmann, Gottfried; Hon, Naven; Houngbédji, Mariano G.; Huffman, Michael A.; Ikemeh, Rachel A.; Imong, Inaoyom; Irwin, Mitchell T.; Izar, Patrícia; Jerusalinsky, Leandro; Kalema‐Zikusoka, Gladys; Kaplin, Beth A.; Kappeler, Peter M.; Kivai, Stanislaus M.; Knott, Cheryl D.; Kolasartsanee, Intanon; Koops, Kathelijne; Kowalewski, Martin M.; Kujirakwinja, Deo; Kumar, Ajith; Le, Quyet K.; Lewis, Rebecca J.; Lin, Aung Ko; Link, Andrés; Loría, Luz I.; Lormie, Menladi M.; Louis, Edward E.; Lwin, Ngwe; Maisels, Fiona; Malaivijitnond, Suchinda; Marisa, Lesley; McCabe, Gráinne M.; McGraw, W. Scott; Mekonnen, Addisu; Méndez‐Carvajal, Pedro G.; Minhós, Tânia; Montgomery, David M.; Morelos‐Juárez, Citlalli; Morgan, Bethan J.; Morgan, David; Etingüe, Amancio Motove; Ndiaye, Papa Ibnou; Nekaris, K. Anne‐Isola; Nguyen, Nga; Nijman, Vincent; Nishuli, Radar; Norconk, Marilyn A.; Oklander, Luciana I.; Oktaviani, Rahayu; Ostner, Julia; Otali, Emily; Perry, Susan E.; Ramos, Eduardo J. Pinel; Porter, Leila M.; Pruetz, Jill D.; Pusey, Anne E.; Queiroz, Helder L.; Ramírez, Mónica A.; Randriatahina, Guy Hermas; Rasoanaivo, Hoby; Ratsimbazafy, Jonah; Ratsirarson, Joelisoa; Razafindramanana, Josia; Razafindratsima, Onja H.; Reynolds, Vernon; Rizaldi, Rizaldi; Robbins, Martha M.; Rodríguez, Melissa E.; Rosales‐Meda, Marleny; Sanz, Crickette M.; Sarkar, Dipto; Savage, Anne; Schreier, Amy L.; Schülke, Oliver; Segniagbeto, Gabriel H.; Serio‐Silva, Juan Carlos; Setiawan, Arif; Seyjagat, John; Silva, Felipe E.; Sinclair, Elizabeth M.; Smith, Rebecca L.; Spaan, Denise; Stewart, Fiona A.; Strum, Shirley C.; Surbeck, Martin; Svensson, Magdalena S.; Talebi, Mauricio; Tédonzong, Luc Roscelin; Urbani, Bernardo; Valsecchi, João; Vasey, Natalie; Vogel, Erin R.; Wallace, Robert B.; Wallis, Janette; Waters, Siân; Wittig, Roman M.; Wrangham, Richard W.; Wright, Patricia C.; Mittermeier, Russell A.Conservation funding is currently limited; cost-effective conservation solutions are essential. We suggest that the thousands of field stations worldwide can play key roles at the frontline of biodiversity conservation and have high intrinsic value. We assessed field stations’ conservation return on investment and explored the impact of COVID-19. We surveyed leaders of field stations across tropical regions that host primate research; 157 field stations in 56 countries responded. Respondents reported improved habitat quality and reduced hunting rates at over 80% of field stations and lower operational costs per km2 than protected areas, yet half of those surveyed have less funding now than in 2019. Spatial analyses support field station presence as reducing deforestation. These “earth observatories” provide a high return on investment; we advocate for increased support of field station programs and for governments to support their vital conservation efforts by investing accordingly.