Browsing by Author "Ribeiro, R."
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- High risk of cardiovascular episodes and low adherence to risk factors guidelines in a population with diabetesPublication . Ribeiro, R.; Matos, P.; Santo, S.; Palma, F.; Pereira, A. M.; Pereira, A.; Graca Ruano, Maria; Boavida, J. M.; Raposo, J. F.Although recent guidelines cover therapeutic goals, effective lipid management of patients with type 1 and type 2 diabetes to reduce cardiovascular disease (CVD) risk is still largely unattained. In the present study, we explored the electronic health records (EHR) at a specialized diabetes outpatient clinic to assess, in a real world database, the prevalence of poor lipid management in people with diabetes, the associated characteristics of this population, and the patterns of medication.
- Identification of DNA markers linked to an induced mutated gene conferring resistance to powdery mildew in pea (Pisum sativum L.)Publication . Pereira, G.; Marques, C.; Ribeiro, R.; Formiga, S.; Damaso, M.; Sousa, M. T.; Farinho, M.; Leitão, J. M.We have recently induced two powdery mildew (Erysiphe pisi Syd) resistant mutants in Pisum sativum L. via ethylnitrosourea (ENU) mutagenesis. Both mutations (er1mut1 and er1mut2) affected the same locus er1 that determines most of the identified natural sources of powdery mildew resistance (PMR) in this crop. The mutated gene er1mut2 was mapped to a linkage group of 16 DNA markers combining three main strategies: near isogenic lines (NILs) analysis, bulked segregant analysis and genetic mapping of randomly identified polymorphic markers, together with three DNA-markers techniques: ISSR, RAPDs and AFLPs. Markers located closer to the PMR locus, OPO06(1100y) (0.5 cM), OPT06(480) (3.3 cM) and AGG/CAA(125) (5.5 cM), were cloned and converted into SCAR markers. Markers AH1R(850) and AHR(920y) were found to be allelic and converted into the co-dominant marker ScAH1 (16.3 cM). Two previously known DNA markers, ScOPE16(1600) and A5(420y,) were mapped at 9.6 and 23.0 cM from the PMR locus, respectively. The novel markers identified in this study are currently being transferred to a new F2 mapping population derived from a cross between the induced PMR mutant line F(er1mut2) and a more genetically distant susceptible line of Pisum sativum var. arvense.
- Identification of DNA markers linked to an induced mutated gene conferring resistance to powdery mildew in pea (Pisum sativum L.)Publication . Pereira, G.; Marques, C.; Ribeiro, R.; Formiga, S.; Damâso, M.; Tavares Sousa, M.; Farinhó, M.; Leitão, J. M.We have recently induced two powdery mildew (Erysiphe pisi Syd) resistant mutants in Pisum sativum L. via ethylnitrosourea (ENU) mutagenesis. Both mutations (er1mut1 and er1mut2) affected the same locus er1 that determines most of the identified natural sources of powdery mildew resistance (PMR) in this crop. The mutated gene er1mut2 was mapped to a linkage group of 16 DNA markers combining three main strategies: near isogenic lines (NILs) analysis, bulked segregant analysis and genetic mapping of randomly identified polymorphic markers, together with three DNA-markers techniques: ISSR, RAPDs and AFLPs. Markers located closer to the PMR locus, OPO061100y (0.5 cM), OPT06480 (3.3 cM) and AGG/CAA125 (5.5 cM), were cloned and converted into SCAR markers. Markers AH1R850 and AHR920y were found to be allelic and converted into the co-dominant marker ScAH1 (16.3 cM). Two previously known DNA markers, ScOPE161600 and A5420y, were mapped at 9.6 and 23.0 cM from the PMR locus, respectively. The novel markers identified in this study are currently being transferred to a new F2 mapping population derived from a cross between the induced PMR mutant line F(er1mut2) and a more genetically distant susceptible line of Pisum sativum var. arvense. © Springer Science+Business Media B.V. 2009.
- Lack of evidence for metallothionein role in tolerance to copper by natural populations of Daphnia longispinaPublication . Martins, N.; Lopes, I.; Guilhermino, L.; Bebianno, Maria João; Ribeiro, R.
- Long COVID-19 fatigue and obstructive sleep apnea: is there a relation?Publication . Pires, L.; Ribeiro, R.; Belchior, I.; Saraiva, C.; Fatal, T.; Guimarães, M. J.; Moniri, Armin; Drummond, M.Fatigue has been reported as the most frequent long COVID-19 symptom. There is a physiological plausibility for relation be tween OSA and long-COVID-19 fatigue, by Intermittent nocturnal hypox emia, endothelial dysfunction, oxidative stress and low grade systemic inflammation. OSA activates the renin-angiotensin-aldosterone system (RAAS) and angiotensin-converting enzyme 2 (ACE2), which is the entry receptor for SARS-CoV-2. The aim of this study is to evaluate if untreated OSA is associated with COVID-19 long-term fatigue.