Browsing by Issue Date, starting with "2023-01-26"
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- Neoadjuvância e metastização no tumor da mama - Estudo de biomarcadores numa série do AlgarvePublication . Susana, Liliana Maria Ferreira; Cartucho, Daniel; Santos, PedroBreast cancer in women is one of the most prevalent tumours nationally and worldwide. Is a type of cancer characterised by its complex aetiology and clinical, morphological, and molecular heterogeneity. We need to know specifically the populations that we attend. Evaluating parameters like histological type, grade, TMN staging, hormone receptors, HER2+ and ki67% status allows for an assessment of the different subtypes (Luminal-A, luminal-B, HER2+ enriched, basal like/Triple Negative (TNBC)), with predictive value regarding prognosis and future therapies. The introduction of neoadjuvant therapy in breast cancer allows for a better control of high-risk metastatic disease. Here, we characterise a series of patients from Algarve with breast cancer who underwent neoadjuvant chemotherapy. A retrospective study was conducted between January 2001 and August 2022, in the Barlavento region, with a total of 254 patients reported. The main years for diagnosis were: 2021 (15,4%), 2012 (9,8%), 2022 (8,3%) and 2016 (7,5%). Mean age was 51,909 ± 12,032 years and median age was 52 years, with ages ranging from 22 to 79 years old. The main subtypes (n=234) obtained were HR+ (37,2%), TNBC (21,8%), triple positive (11,1%) and ER+ (10,3%). The main molecular subtypes (n=104) were: Basal-like (35,6%), Luminal-A (25,0%) and Luminal-B (22,1% of all cases). We also verified a statistic association between the type of therapeutic response for QTNA and the histologic subtype where, for a complete response, there is a higher number of TNBC (p-value=0,000), HER2+ and triple positives tumours (p-value=0,000). From the results, it was possible to observe that the HER2+ subtype was not the most prevalent. Our population was younger than expected. It is crucial to characterize the population we treat. This study has given us a better characterization of the breast cancer problem in Algarve and provides a series of clues for future depth and analysis of this data.
- Holocene glaucony from the Guadiana shelf, Northern Gulf of Cadiz (SW Iberia): New genetic insights in a sequence stratigraphy contextPublication . López-Quirós, Adrián; Lobo, Francisco José; Mendes, Isabel; Nieto, FernandoGlaucony occurrences have been reported both from exposed transgressive and overlying highstand system tracts. However, its occurrences within highstand deposits are often invoked as the result of underlying condensed section reworking. Detailed textural, mineralogical and geochemical reports of glaucony grains in highstand deposits remain elusive. The northern Gulf of Cadiz shelf (SW Iberia) offers a unique opportunity to investigate late Holocene glaucony authigenesis in a well-documented time-stratigraphic context, where transgressive deposits are locally exposed on the seafloor and are laterally draped by highstand muddy deposits. In this study, glaucony grains extracted from a core retrieved from a highstand muddy depocenter off the Guadiana River were investigated by means of digital microscopy, X-ray diffraction (XRD), and electron microscopic methods (FESEM-EDX and TEM-HRTEM). To better constrain the glaucony origin (autochthonous vs. allochthonous) in highstand muddy deposits, glaucony grains from surficial samples—taken from exposed transgressive deposits—were also investigated. Glauconitization in the studied core can be largely attributed to the replacement of faecal pellets from c. ~4.2–1.0 cal. ka BP. Both XRD and TEM-HRTEM analyses indicate that glaucony consists mainly of an R1, with a minor presence of R0, smectite-rich (nontronite) glauconite-smectite mixed-layer silicate, made up of 35–75% glauconitic layers and 65–25% of interstratified smectite layers. At the mineral lattice level, minor individual 7Å layers (berthierine) were also identified by HRTEM. Shallow radial cracks at the pellet surface, along with globular and vermiform-like biomorphic to low packing density lamellar-flaky nanostructures, mineralogical properties, and K-poor content (average 0.4 atoms p.f.u.) indicate a scarcely mature glauconitization process, attesting to formation of the grains in situ (autochthonous). Glaucony grains from exposed transgressive deposits, i.e., in the tests of calcareous benthic foraminifera, do not share a genetic relationship with the grains investigated in the highstand deposits, thus supporting the autochthonous origin of glaucony within the highstand deposits. Our combined dataset provides evidence of a multiphase history for autochthonous glaucony formation in the Guadiana shelf, as its genesis is traced to both transgressive and highstand conditions. While eustatic sea-level changes favoured glaucony formation under transgressive conditions, factors such as protracted low sediment supply and the establishment of a strong nutrient-rich upwelling system in the study area promoted glaucony development during late Holocene highstand conditions.
- Ética e desempenho organizacional uma investigação sobre as empresas do AlgarvePublication . Gonçalves, Eunice Luís Candeias; Jesus, Maria Margarida Nascimento; Marques, João FilipeAs questões da ética empresarial assumem grande relevância nas sociedades contemporâneas, constituindo a ética um fio de prumo capaz de orientar a atuação das empresas. Trata-se de uma temática que pela sua complexidade ainda é fruto de alguma polémica, contudo a sua pertinência e importância tem continuado a despertar o interesse de numerosos investigadores. A presente dissertação abordou o tema da ética empresarial e teve como principal objetivo estudar as variáveis de natureza ética que poderiam influenciar o desempenho organizacional. A revisão da literatura permitiu definir os conceitos e os desenvolvimentos teóricos mais importantes relacionados com o tema. Permitiu também elencar um conjunto de variáveis que podem influenciar o desempenho organizacional, nomeadamente, gestão ética, liderança virtuosa, clima organizacional ético, código de ética, responsabilidade social da empresa e compliance. A investigação empírica, que incidiu sobre uma amostra de empresas do Algarve, contemplou uma abordagem de natureza quantitativa. Foi aplicado um inquérito por questionário aos trabalhadores e aos gestores de empresas localizadas na região. Os dados recolhidos foram tratados com recurso a técnicas de análise univariada, para caracterizar a amostra e multivariada, para estabelecer uma tipologia das empresas do Algarve a partir do seu posicionamento ético, tendo-se utilizado o método Two-step Cluster Analysis. O estudo permitiu identificar quatro tipologias de empresas algarvias relativamente ao seu posicionamento ético. Os resultados demostraram que as empresas da amostra têm preocupações de natureza ética, não tendo sido encontrados casos de manifesta falta de ética. Concluiu-se, ainda, que a variável código de ética é a que mais distingue as empresas entre si, tendo sido a que mais contribuiu para a formação dos clusters.