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- Decent work and burnout: the moderating role of career callingPublication . Faria, Liliana; Porto, SofiaBurnout is a critical issue in occupational mental health, and decent work is recognised as a key factor in promoting employee well-being. Drawing on the Psychology of Working Theory and Conservation of Resources Theory, this study examined whether Career Calling, as a personal resource, moderates the relationship between Decent Work and Burnout among Portuguese workers. A cross-sectional online survey was conducted with 173 participants, and data were analyzed using the PROCESS macro. Results indicated a significant negative relationship between Decent Work and Burnout, with Career Calling moderating this association: its protective effect was stronger when decent work conditions were adequate. These findings highlight the importance of prioritising decent work as the primary strategy to prevent burnout, while supporting the development of Career Calling as a complementary resource to enhance resilience, engagement, and meaning in work.
- Editorial: (un)healthy lifestyles, aging, and type 2 diabetesPublication . Duarte-Mendes, Pedro; Fernanda M. Silva; Teixeira, Ana M.Recent estimates from the IDF Diabetes Atlas indicate that diabetes affects 589 million adults worldwide in 2024, with type 2 diabetes (T2D) accounting for more than 90% of cases (International Diabetes Federation, 2025). This number is projected to reach 853 million by 2050. Age is an important risk factor for T2D, with estimates indicating that one in four adults with the disease (158 million) are over 65 years old. Poor lifestyle factors, such as lack of exercise, sedentary behavior, and poor diet, are important underlying factors in the development of obesity and insulin resistance, leading to T2D and cardiovascular disease (Lu et al., 2024; Bowden Davies et al., 2018). On the other hand, effective interventions, such as regular exercise and a healthy diet, have been recommended to improve glucose metabolism in both diabetic and non-diabetic individuals (Silva et al., 2024; Syeda et al., 2023; Kim and Kwon, 2024). In addition to engaging in regular exercise, studies have demonstrated the benefits of interrupting sitting time with regular bouts of movement (Syeda et al., 2023). Given the high prevalence of T2D, mainly in the middle-aged and elderly population, it is important to investigate the impact of (un)healthy lifestyles on metabolic markers and to create a set of strategies to prevent or control T2D and its related complications. This Research Topic, Editorial: (Un)healthy lifestyles, Aging, and Type 2 Diabetes, addresses these questions through nine complementary contributions.
- Syngap1 and the development of murine neocortical progenitor cellsPublication . Barao, Soraia; Xu, Yijun; Hong, Ingie; Müller, Ulrich; Huganir, Richard L.SYNGAP1 regulates synaptic plasticity through interactions with scaffold proteins and modulation of Ras and Rap GTPase signaling. Human SYNGAP1 mutations are linked to intellectual disability, epilepsy, and autism. In mice, Syngap1 haploinsufficiency causes impaired LTP, premature maturation of dendritic spines, learning disabilities, and seizures, reflecting the human phenotypes of SYNGAP1 syndrome. Recently, SYNGAP1 was shown to influence cortical neurogenesis and progenitor proliferation in human organoids. Here, we show that Syngap1 absence or haploinsufficiency does not alter neocortical progenitors and their cellular output in mice. Despite careful analysis of cortical progenitor properties, we fail to replicate the main findings from human organoids. This discrepancy suggests species-specific or methodological differences and raises questions about the broader relevance of SYNGAP1’s role in neurogenesis. The absence of cortical progenitor deficits in haploinsufficient mice, which exhibit cognitive deficits and seizures, indicates these arise from SYNGAP1’s regulation of synapse function rather than its role on neurogenesis.