FCT2-Artigos (em revistas ou actas indexadas)
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Percorrer FCT2-Artigos (em revistas ou actas indexadas) por Objetivos de Desenvolvimento Sustentável (ODS) "10:Reduzir as Desigualdades"
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- Advanced nanotherapeutic strategies transforming diabetic wound healingPublication . Ramos, Filipa; Kumar, Girish; Virmani, Tarun; Sharma, Abhishek; Duarte, Sofia O. D.; Fonte, PedroDue to their high recurrence rates and slow healing, diabetic wounds are becoming a greater public health concern [Citation1]. Each year, 1.6 million cases of diabetic wounds occur in the United States alone, affecting approximately 18.6 million people worldwide [Citation2]. Because of poor cellular regeneration, increased inflammation, and reduced angiogenesis, traditional treatments like debridement, antibiotics, and dressings usually do not work [Citation3]. To overcome the limitations of traditional treatments, there is now a significant demand for advanced therapeutic modalities that promise accurate, efficient, and rapid healing processes [Citation4]. These include microneedles (MNs), exosomes, tetrahedral framework nucleic acids (tFNAs), three-dimensional scaffolds, gene therapy, oxygen-releasing biomaterials, phototherapies, and nanozymes.
- LINA: an augmented reality social game enhancing sense of belonging among classmates: an uncontrolled pre-post evaluation studyPublication . Krammer, Ina; Mittmann, Gloria; Nater, Urs M.; Barnard, Adam; Martins, Diogo; Dias, João; Schrank, Beate; Woodcock, Kate A.Supportive peer relationships are fundamental in the development of well-being. Since early adolescents spend a lot of time at school, especially in their classroom, a sense of belonging among classmates plays a pivotal role for mental health and academic functioning. Programs that enhance sense of belonging among classmates through improving peer relationships in classrooms are rare. Given that early adolescents increasingly use digital media to establish and maintain relationships with classmates, there is potential in digital social games that enhance social connectivity and collaboration, especially during the difficult transition from primary to secondary school. LINA ('Lina Is Not Alone') is a novel social augmented reality game for classrooms that is designed to enhance sense of belonging among classmates through improving their relationships with classmates. We conducted an uncontrolled pre-post evaluation study to evaluate (a) player experience, (b) translation of the theory-led LINA design into user experience and (c) increases in sense of belonging after engagement with LINA. In total, data from 99 participants (Mage = 10.94; range = 10-12; 51 girls, 48 boys) were included in this study. Our results provided evidence for (a) high satisfaction and acceptability of LINA, (b) a successful translation of theory-led design features into user experiences, and (c) increases in sense of belonging. We discuss practical implications and future development of LINA.
- MentalRAG: developing an agentic framework for therapeutic support systemsPublication . Silva, Francisco; Santos, Pedro; Dias, JoãoThis paper introduces MentalRAG, a multi-agent system built upon an agentic framework designed to support mental health professionals through the automation of patient data collection and analysis. The system effectively gathers and processes high-sensitivity mental health data from users. It employs locally run opensource models for most tasks, while leveraging advanced state-of-the-art models for more complex analyses, ensuring the maintenance of data anonymity. The system’s models have showed improvements in delivering empathetic and contextually adaptive responses, particularly in sensitive contexts such as emotional distress and crisis management. Notably, an integrated agent for detecting levels of suicidal ideation allows the system to assess and respond sensitively to diverse levels of risk, promptly alerting mental health professionals as needed. This innovation represents a stride towards creating a more reliable, efficient, and ethically responsible mental health support tool, capable of addressing both patient and doctor needs effectively while minimizing associated risks.
- Perspectives of people living with Type 2 diabetes about physical activity promotion: can community pharmacies be part of the solution?Publication . Viegas, Ruben; Moura, Izabela; Cavaco, Afonso; Ramos, Filipa Duarte; Mendes, Romeu; Costa, Filipa Alves daRationale: People living with type 2 diabetes (T2D) benefit from regular physical activity (PA) to reduce cardiovascular risk and better manage comorbidities. Pharmacists can provide support to increase physical activity by leveraging the regular interactions on their daily community pharmacy practice. Aims and Objectives: This study aimed to explore the perspectives of people living T2D about their engagement in PA using pharmacies as the subject of interest to collect this information. Methods: This study followed a focus group technique using a semi‐structured guide. People living with T2D were recruited in community pharmacies resorting to typical case sampling. Five in person focus group interviews with 23 patients living with T2D were conducted by the research team. Interviews were recorded following consent, transcribed verbatim, coded independently by two researchers and analysed using the socio‐ecologic model. Results: A total of 23 people living with T2D were interviewed. Aspects determining PA engagement ranged from individual aspects such as physical limitations; interpersonal aspects such as having a reference pharmacist; organisational aspects such as activities done through the pharmacy; community aspects such as the cost of exercise activities and policy aspects such as information registry. Conclusions: This study suggests that community pharmacies are currently not considered by people living with diabetes as a source for behaviour change linked to PA but explores possible ways on how this could become a reality in the future.
- Telehealth for integrated cardiovascular and diabetes management: a scoping reviewPublication . Estêvão, Maria Dulce da Mota Antunes de Oliveira ; Teotónio Fernandes, Mónica Alexandra; De Sousa-Coelho, Ana Luísa; Neto Espírito-Santo, Margarida de Fátima; Nascimento, Tânia; Alfredo CaturanoCardiovascular disease (CVD) and diabetes mellitus represent major global health challenges, frequently co-occurring and mutually exacerbating. Telehealth interventions offer a promising approach for their management, with potential to improve patient outcomes, enhance access to care, and increase cost-effectiveness. This review synthesized existing evidence from randomized controlled trials (RCTs) and observational studies to evaluate the effectiveness of telehealth interventions for the management of diabetes, focusing on CVD risk, and to identify critical research gaps. A systematic literature search was conducted across major databases (PubMed, Web of Science, and Scopus) to identify studies meeting predefined eligibility criteria, considering digital tools for remote monitoring, consultation, education, and medication management. After the screening of 3041 articles, six studies met the inclusion criteria. Telehealth interventions utilized a range of digital health tools, including mobile applications, artificial intelligence–powered clinical decision aids, electronic consultations, and integrated remote monitoring platforms. Although direct assessment of composite cardiovascular risk was largely absent, the included studies reported several clinical parameters associated with cardiovascular health, namely, blood pressure, lipid profile, and glycated hemoglobin. Telehealth interventions implemented for individuals with Type 2 diabetes mellitus demonstrated promising potential in improving glycemic control and supporting self-management. However, their effectiveness in managing broader cardiovascular risk factors remains less clear due to inconsistent reporting and heterogeneous intervention designs.
- Topical insulin meets nanomedicine: a synergy for enhanced skin regenerationPublication . Duarte, Sofia O. D.; Fonte, PedroChronic wounds, particularly those associated with diabetes, present an increasing public health burden due to their extended healing periods and high recurrence rates. One of the most common and clinically difficult forms of chronic wounds are diabetic foot ulcers, which are frequently distinguished by poor angiogenesis, ongoing inflammation, and wound environments that are rich in proteases. Over10 million people are impacted in Europe alone, with a high prevalence among those 65 and older. Over €4 billion is spent on healthcare each year, with each patient’s treatment costing between €6,000 and €10,000 [1,2]. Because of the ongoing inflammation and protease activity, conventional therapies frequently fail to promote complete regeneration, particularly in diabetic wound beds where heal-ing is severely compromised. As a result, there is now more interest in insulin, a biomolecule that is vital for wound heal-ing and has angiogenic, proliferative, and immunomodulatory qualities [2]. However, in chronic wound beds, insulin is extremely vulnerable to enzymatic degradation [3]. By encapsulating insulin in nanoparticles that resist degradation, enhance retention at the wound site, and permit con-trolled release, recent developments in nanomedicine overcome these drawbacks. These technologies better match drug availability with the changing wound environment and improve the regenerative effects of insulin [3,4]. As a result, combining topical insulin therapy with nanocarrier systems shows promise as a wound care approach, especially for diabetic ulcers and other chronic conditions.