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- Role of MOB4 in cell proliferation and neurogenesisPublication . Baião Santos, Inês; GARRIDO-MARAVER, JUAN; Gonçalves, Carolina; Oliveira, Bruna; Tavares, Alvaro A.Signaling pathways that integrate a large set of inputs (both extra- and intracellular) to control cell proliferation are essential during both development and adult stages to guarantee organism homeostasis. Mobs are small adaptor proteins that participate in several of these signaling pathways. Here, we review recent advances unravelling Mob4 cellular functions, a highly conserved non-catalytic protein, that plays a diversity of roles in cell proliferation, sperm cell differentiation and is simultaneously involved in synapse formation and neural development. In addition, the gene is often overexpressed in a large diversity of tumors and is linked to poor clinical outcomes. Nevertheless, Mob4 molecular functions remain poorly defined, although it integrates the core structure of STRIPAK, a kinase/phosphatase protein complex, that can act upstream of the Hippo pathway. In this review we focus on the recent findings of Mob4 functions, that have begun to clarify its critical role on cell proliferation and the development of tissues and individuals.
- First person – Juan Garrido-MaraverPublication . Garrido-Maraver, JuanFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Juan Garrido-Maraver is first author on 'Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease', published in BiO. Juan conducted the research described in this article while a postdoctoral scientist in L. Miguel Martins's lab at the MRC Toxicology Unit, University of Cambridge, Leicester, UK. He is now a postdoctoral scientist in the lab of Alvaro A. Tavares at the Centre for Biomedical Research (CBMR), University of Algarve, Faro, Portugal, investigating molecular mechanisms linked to human diseases from a therapeutic point of view.