Role of MOB4 in cell proliferation and neurogenesis

Baião Santos, Inês; GARRIDO-MARAVER, JUAN; Gonçalves, Carolina; Oliveira, Bruna; Tavares, Alvaro A.

http://hdl.handle.net/10400.1/20277

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Authors

Baião Santos, Inês

GARRIDO-MARAVER, JUAN

Gonçalves, Carolina

Oliveira, Bruna

Tavares, Alvaro A.

Abstract(s)

Signaling pathways that integrate a large set of inputs (both extra- and intracellular) to control cell proliferation are essential during both development and adult stages to guarantee organism homeostasis. Mobs are small adaptor proteins that participate in several of these signaling pathways. Here, we review recent advances unravelling Mob4 cellular functions, a highly conserved non-catalytic protein, that plays a diversity of roles in cell proliferation, sperm cell differentiation and is simultaneously involved in synapse formation and neural development. In addition, the gene is often overexpressed in a large diversity of tumors and is linked to poor clinical outcomes. Nevertheless, Mob4 molecular functions remain poorly defined, although it integrates the core structure of STRIPAK, a kinase/phosphatase protein complex, that can act upstream of the Hippo pathway. In this review we focus on the recent findings of Mob4 functions, that have begun to clarify its critical role on cell proliferation and the development of tissues and individuals.