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- Avaliação do potencial das Tiazolidinedionas como estratégia terapêutica no MelanomaPublication . Espírito Santo, Margarida; De Sousa-Coelho, Ana Luísa; Ana Patrícia, PintoO melanoma é uma doença mundial que representa a forma mais agressiva de cancro da pele com incidência e mortalidade em contínuo aumento. Apesar de existirem terapêuticas direcionadas às mutações específicas no melanoma, a resistência adquirida pelos doentes ao tratamento constitui uma barreira ao sucesso da terapêutica, suscitando assim a necessidade de identificação de novos fármacos e novas opções terapêuticas. Nos últimos anos tem surgido grande interesse na potencial utilização de antidiabéticos orais, como a metformina (biguanida) no tratamento do melanoma. As tiazolidinedionas (TZDs), agonistas do receptor PPARγ, são também uma classe de fármacos utilizados no tratamento da diabetes tipo 2.
- Potential impact of metabolic syndrome control on cardiovascular risk in elderly patients with diabetes: a cross-sectional studyPublication . Nascimento, Tânia; Estêvão, Maria Dulce da Mota Antunes de Oliveira ; Gonçalves, Adriana; Pinto, Ezequiel; De Sousa-Coelho, Ana Luísa; Neto Espírito-Santo, Margarida de FátimaMetabolic syndrome (MS), a complex pathology with features like abnormal body fat distribution, insulin resistance, and dyslipidaemia, contributes to higher cardiovascular (CV) risk. A cross-sectional study including 87 individuals assessed CV risk score in elderly patients with type 2 diabetes and MS in Algarve, Portugal. The 10-year CV risk score was estimated using the ADVANCE risk score calculator. The reductions in CV risk score were estimated by adjusting the data inputted on the online tool to achieve systolic blood pressure (SBP) <130 or <120 mmHg, and LDL cholesterol <70 mg/dL Beyond waist circumference, the mean number of clinical features of MS was 3.14 ± 0.84, without significant sex differences. The mean CV risk score was 22.5% (CI: 20.3–24.7). Sex-specific analysis showed higher risk score in males (24.2%, CI: 21.3–27.0) vs. females (19.7%, CI: 16.2–23.3; p = 0.028). Hypothetical risk score reductions show that lowering SBP to <130 mmHg could significantly lower the risk score by an average of 9.2% (CI: 7.7–10.7), whereas 34.5% of the participants would be out of the diagnostic criteria for MS. When comparing each potential intervention with current risk score, all interventions significantly reduce the 10-year CV risk score. The study highlights the potential of blood pressure control in reducing CV risk score and the importance of multifaceted risk score reduction strategies.
- Statement of Peer ReviewPublication . De Sousa-Coelho, Ana Luísa; Teotónio Fernandes, Mónica Alexandra; Estêvão, Maria Dulce da Mota Antunes de Oliveira ; Neto Espírito-Santo, Margarida de Fátima; Braz, Luis; Nascimento, TâniaIn submitting conference proceedings to Proceedings, the volume editors of the proceedings certify to the publisher that all papers published in this volume have been subjected to peer review administered by the volume editors. The reviews were conducted by expert referees, and to the professional and scientific standards expected of a proceedings journal.