MOLECULAR AND FUNCTIONAL CHANGES IN FAMILIAL NON-MEDULLARY THYROID CANCER

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Organizational Unit

Publications

Gene expression during regeneration of zebrafish (danio rerio) fins: relative expression levels of mineralization – related gla proteins

Publication . Brito, A. B.; Gavaia, Paulo J.; Cancela, Leonor

Most animals have the ability to regenerate epidermal injuries yet only a few can regenerate largely severed appendages that comprise several different tissues. Nowadays zebrafish is one of the most used metazoan models in regeneration studies in particular for investigation of molecular events during fin regeneration process. Fin regeneration starts through the formation of a blastema, a set of heterogeneous mesenchyma-like cells located between stump tissues and the wounded epidermis. This event, denominated epimorphic regeneration, comprises strict growth control and cell reprogramming leading to faithful restoration of the lost parts.

2007Conference object

Open access

Gene expression during regeneration of zebrafish (danio rerio) fins: relative expression levels of mineralization–related gla proteins

Publication . Brito, A. B.; Gavaia, Paulo J.; Cancela, Leonor

Most animals have the ability to regenerate epidermal injuries yet only a few can regenerate largely severed appendages that comprise several different tissues. Nowadays zebrafish is one of the most used metazoan models in regeneration studies in particular for investigation of molecular events during fin regeneration process. Fin regeneration starts through the formation of a blastema, a set of heterogeneous mesenchyma-like cells located between stump tissues and the wounded epidermis. This event, denominated epimorphic regeneration, comprises strict growth control and cell reprogramming leading to faithful restoration of the lost parts.

2007Conference object

Unknown

Expression of osteonectin correlates with levels of fin regeneration in zebrafish (Danio rerio

Publication . Brito, A. B.; Cancela, Leonor; Gavaia, Paulo J.

Mammals have the ability to regenerate some tissues such as blood and liver, but the majority of organs fail to regenerate. In contrast, zebrafish is capable of regenerating complex organs/tissues such as optic nerve, scales, heart and fins, and is presently one of the most used metazoan in regeneration research. Zebrafish fin is composed of multiple fin rays with bony parts (lepidotrichia) originated by intramembraneous ossification. Fin regeneration is an epimorphic process dependent on formation of a specialized structure (blastema), consisting of mesenchymal-like cells located between stump tissues and the wounded epidermis,

2007Conference object

Unknown