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Chemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from Turkey
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Orientador(es)
Resumo(s)
Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the
first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the
hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from
N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g)
and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40
and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and
129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity
assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract
against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed
high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the
methanol and water extracts. The results obtained from this study highlighted that the abundance
of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the
tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and
therefore should be investigated further.
Descrição
Palavras-chave
Nepeta Polyphenols Antioxidant Enzyme inhibition Phytopharmaceutics
Contexto Educativo
Citação
Plants 10 (6): 1176 (2021)
Editora
MDPI