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Chemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from Turkey

2021-06-09Journal article Open Access
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dc.contributor.authorZengin, Gokhan
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorAktumsek, Abdurrahman
dc.contributor.authorJekő, József
dc.contributor.authorCziáky, Zoltán
dc.contributor.authorRodrigues, Maria João
dc.contributor.authorCustódio, Luísa
dc.contributor.authorPolat, Rıdvan
dc.contributor.authorCakilcioglu, Ugur
dc.contributor.authorAyna, Adnan
dc.contributor.authorGallo, Monica
dc.contributor.authorMontesano, Domenico
dc.contributor.authorPicot-Allain, Carene
dc.date.accessioned2021-06-28T09:25:03Z
dc.date.available2021-06-28T09:25:03Z
dc.date.issued2021-06-09
dc.date.updated2021-06-24T14:10:39Z
dc.description.abstractNepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifierdoi: 10.3390/plants10061176
dc.identifier.citationPlants 10 (6): 1176 (2021)pt_PT
dc.identifier.doi10.3390/plants10061176pt_PT
dc.identifier.issn2223-7747
dc.identifier.urihttp://hdl.handle.net/10400.1/16669
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNepetapt_PT
dc.subjectPolyphenolspt_PT
dc.subjectAntioxidantpt_PT
dc.subjectEnzyme inhibitionpt_PT
dc.subjectPhytopharmaceuticspt_PT
dc.titleChemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from Turkeypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.startPage1176pt_PT
oaire.citation.titlePlantspt_PT
oaire.citation.volume10pt_PT
person.familyNameRodrigues
person.familyNameCustódio
person.givenNameMaria João
person.givenNameLuísa
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscovery12c32925-de9e-4289-bdd5-1d655d7a278c

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