Repository logo
 
Publication

Dawson- and lindqvist-type hybrid polyoxometalates: synthesis, characterization and Ca2+-ATPase inhibition potential

2025-11-07Journal article Open access
Simple item page
dc.contributor.authorMeskini, Islem
dc.contributor.authorCapet, Frédéric
dc.contributor.authorFraqueza, Gil
dc.contributor.authorDege, Necmi
dc.contributor.authorTahir, Muhammad Nawaz
dc.contributor.authorAyed, Brahim
dc.contributor.authorAureliano, Manuel
dc.date.accessioned2026-01-07T12:25:31Z
dc.date.available2026-01-07T12:25:31Z
dc.date.issued2025-11-07
dc.description.abstractPolyoxometalates (POMs) represent a broad class of anionic inorganic (V, Mo, W) clusters with versatile structures of chemical and physical properties. POMs are inhibitors of many enzymes, including P-type ATPases, well-known to be a target of several approved drugs. Herein, two new hybrid POMs with Mo and mixed V/W, namely (C2H8N1)6[V2Mo18O62].3H2O (1) and (C4H16N3)4[V2W4O19]3.12H2O (2), were synthesized via wet chemical methods in aqueous solution, and their purity was confirmed and characterized by single X-ray diffraction and infrared spectroscopy. The cations are dimethylammonium ((C2H8N)+ ) and diethylenetriammonium ((C4H16N3) 3+), respectively. POMs biological activities were investigated, specifically their inhibitory potential against Ca2+-ATPase. The sarcoplasmic reticulum Ca2+-ATPase activities were measured spectrophotometrically using the coupled enzyme pyruvate kinase/lactate dehydrogenase assay. For the Ca2+-ATPase activity, Dawson (1) showed an IC50 value of 3.4 µM, whereas Lindqvist (2) displayed a value of 45.1 µM. The Ca2+-ATPase inhibitory potential of these POMs can be correlated with the net charge (namely 6- and 4-) and the charge density (namely 0.33 and 0.67). A structure–activity-relationship was established for a series of 17 POMs Ca2+-ATPase inhibitors correlating IC50 values and POMs net charge and POMs charge density. The described features make Dawson (1) and Lindqvist (2) attractive POMs in a wide range of chemistry fields as well as in biomedical applications.eng
dc.description.sponsorshipUID/04326/2025; UID/PRR/04326/2025; EMBRC.PT ALG-01-0145-FEDER-022121
dc.identifier.doi10.3390/molecules30224334
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.1/28061
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationCentre for Marine and Environmental Research
dc.relation.ispartofMolecules
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPolyoxometalates
dc.subjectCa2+-ATPase inhibitors
dc.subjectPOMs synthesis
dc.subjectCoupled enzyme pyruvate kinase/lactate dehydrogenase assay
dc.subjectStructure-activity correlations
dc.titleDawson- and lindqvist-type hybrid polyoxometalates: synthesis, characterization and Ca2+-ATPase inhibition potentialeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.issue22
oaire.citation.startPage4334
oaire.citation.titleMolecules
oaire.citation.volume30
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFraqueza
person.familyNameAureliano
person.givenNameGil
person.givenNameManuel
person.identifier1179689
person.identifier584146
person.identifier.ciencia-id1317-C7C9-5BDA
person.identifier.ciencia-idAA14-3490-DC5E
person.identifier.orcid0000-0003-2969-9292
person.identifier.orcid0000-0003-4858-3201
person.identifier.ridA-3552-2013
person.identifier.ridI-3283-2012
person.identifier.scopus-author-id54683851800
person.identifier.scopus-author-id6603412860
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication9e7ef53d-b79c-4446-9093-0611980e6ecd
relation.isAuthorOfPublicationbb413661-7edd-4b57-8338-33889cfd05db
relation.isAuthorOfPublication.latestForDiscovery9e7ef53d-b79c-4446-9093-0611980e6ecd
relation.isProjectOfPublication794d4c77-c731-471e-bc96-5a41dcd3d872
relation.isProjectOfPublication.latestForDiscovery794d4c77-c731-471e-bc96-5a41dcd3d872

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
molecules-30-04334-v2.pdf
Size:
2.97 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.46 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCT2-Artigos (em revistas ou actas indexadas)