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What is the role of apelin regarding cardiovascular risk and progression of renal disease in type 2 diabetic patients with diabetic nephropathy?

2013Journal article Open Access
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dc.contributor.authorSilva, Ana Paula
dc.contributor.authorFragoso, Andre
dc.contributor.authorSilva, Claudia
dc.contributor.authorViegas, Carla
dc.contributor.authorTavares, Nelson
dc.contributor.authorGuilherme, Patricia
dc.contributor.authorSantos, Nelio
dc.contributor.authorRato, Fatima
dc.contributor.authorCamacho, Ana
dc.contributor.authorCavaco, Cidalia
dc.contributor.authorPereira, Victor
dc.contributor.authorFaisca, Marilia
dc.contributor.authorAtaide, Joao
dc.contributor.authorJesus, Ilidio
dc.contributor.authorNeves, Pedro LeĂŁo
dc.date.accessioned2018-12-07T14:58:29Z
dc.date.available2018-12-07T14:58:29Z
dc.date.issued2013
dc.description.abstractAims. To evaluate the association of different apelin levels with cardiovascular mortality, hospitalization, renal function, and cardiovascular risk factors in type 2 diabetic patients with mild to moderate CKD. Methods. An observational, prospective study involving 150 patients divided into groups according to baseline apelin levels: 1 <= 98pg/mL, 2 = 98-328 pg/mL, and 3 >= 329 pg/mL. Baseline characteristics were analyzed and compared. Multivariate Cox regression was used to find out predictors of cardiovascular mortality, and multivariate logistic regression was used to find out predictors of hospitalization and disease progression. Simple linear regressions and Pearson correlations were used to investigate correlations between apelin and renal disease and cardiovascular risk factors. Results. Patients' survival at 83 months in groups 1, 2, and 3 was 39%, 40%, and 71.2%, respectively (P = 0.046). Apelin, age, and eGFR were independent predictors of mortality, and apelin, creatinine, eGFR, resistin, and visfatin were independent predictors of hospitalization. Apelin levels were negatively correlated with cardiovascular risk factors and positively correlated with eGFR. Patients with lower apelin levels were more likely to start a depurative technique. Conclusions. Apelin levels might have a significant clinical use as a marker/predictor of cardiovascular mortality and hospitalization or even as a therapeutic agent for CKD patients with cardiovascular disease.
dc.identifier.doi10.1155/2013/247649
dc.identifier.issn2314-6133
dc.identifier.urihttp://hdl.handle.net/10400.1/12050
dc.language.isoeng
dc.peerreviewedyes
dc.publisherHindawi Publishing Corporation
dc.subjectHomeostasis
dc.subjectFailure
dc.titleWhat is the role of apelin regarding cardiovascular risk and progression of renal disease in type 2 diabetic patients with diabetic nephropathy?
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage247649
oaire.citation.titleBioMed Research International
person.familyNameViegas
person.familyNameNeves
person.givenNameCarla
person.givenNamePedro LeĂŁo
person.identifier.ciencia-idC414-F596-EEC6
person.identifier.ciencia-id1014-3EA2-C680
person.identifier.orcid0000-0002-5765-3665
person.identifier.orcid0000-0002-8463-0768
person.identifier.ridN-6695-2014
person.identifier.scopus-author-id8656310300
person.identifier.scopus-author-id7003907170
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication33984b3c-ffac-477a-896a-ddbf7aced4e3
relation.isAuthorOfPublication788c02e9-1087-4e30-8a34-5379261fc739
relation.isAuthorOfPublication.latestForDiscovery33984b3c-ffac-477a-896a-ddbf7aced4e3

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