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Thyroid and pituitary gland development from hatching through metamorphosis of a teleost flatfish, the Atlantic halibut

2006Journal article Open access
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dc.contributor.authorEinarsdóttir, Ingibjörg E.
dc.contributor.authorSilva, Nadia
dc.contributor.authorPower, Deborah
dc.contributor.authorSmaàradóttir, Heiddis
dc.contributor.authorBjörnsson, Björn Thrandur
dc.date.accessioned2014-10-24T12:36:24Z
dc.date.available2014-10-24T12:36:24Z
dc.date.issued2006
dc.description.abstractFish larval development, not least the spectacular process of flatfish metamorphosis, appears to be under complex endocrine control, many aspects of which are still not fully elucidated. In order to obtain data on the functional development of two major endocrine glands, the pituitary and the thyroid, during flatfish metamorphosis, histology, immunohistochemistry and in situ hybridization techniques were applied on larvae of the Atlantic halibut (Hippoglossus hippoglossus), a large, marine flatfish species, from hatching through metamorphosis. The material was obtained from a commercial hatchery. Larval age is defined as day-degrees (D =accumulated daily temperature from hatching). Sporadic thyroid follicles are first detected in larvae at 142 D (27 days post-hatch), prior to the completion of yolk sack absorption. Both the number and activity of the follicles increase markedly after yolk sack absorption and continue to do so during subsequent development. The larval triiodothyronine (T3) and thyroxine (T4) content increases, subsequent to yolk absorption, and coincides with the proliferation of thyroid follicles. A second increase of both T3 and T4 occurs around the start of metamorphosis and the T3 content further increases at the metamorphic climax. Overall, the T3 content is lower than T4. The pituitary gland can first be distinguished as a separate organ at the yolk sack stage. During subsequent development, the gland becomes more elongated and differentiates into neurohypophysis (NH), pars distalis (PD) and pars intermedia (PI). The first sporadic endocrine pituitary cells are observed at the yolk sack stage, somatotrophs (growth hormone producing cells) and somatolactotrophs (somatolactin producing cells) are first observed at 121 D (23 days post-hatch), and lactotrophs (prolactin producing cells) at 134 D (25 days post-hatch). Scarce thyrotrophs are evident after detection of the first thyroid follicles (142 D ), but coincident with a phase in which follicle number and activity increase (260 D ). The somatotrophs are clustered in the medium ventral region of the PD, lactotrophs in the anterior part of the PD and somatolactotrophs are scattered in the mid and posterior region of the pituitary. At around 600 D , coinciding with the start of metamorphosis, somatolactotrophs are restricted to the interdigitating tissue of the NH. During larval development, the pituitary endocrine cells become more numerous. The present data on thyroid development support the notion that thyroid hormones may play a significant role in Atlantic halibut metamorphosis. The time of appearance and the subsequent proliferation of pituitary somatotrophs, lactotrophs, somatolactotrophs and thyrotrophs indicate at which stages of larval development and metamorphosis these endocrine cells may start to play active regulatory roles.por
dc.description.sponsorshipThis work has been carried out within the projects ‘‘Endocrine Control as a Determinant of Larval Quality in Fish Aquaculture’’ (CT-96-1422) and ‘‘Arrested development: The Molecular and Endocrine Basis of Flatfish Metamorphosis’’ (Q5RS-2002-01192), with financial support from the Commission of the European Communities. However, it does not necessarily reflect the Commission’s views and in no way anticipates its future policy in this area. This project was further supported by the Swedish Council for Agricultural and Forestry Research and Pluriannual funding to CCMAR by the Portuguese Science and Technology Council.por
dc.identifier.citationIngibjörg Eir Einarsdóttir Æ Nadia Silva Deborah M. Power Æ Heiddis Smáradóttir Björn Thrandur Bjornsson, "Thyroid and pituitary gland development from hatching through metamorphosis of a teleost flatfish, the Atlantic halibut" in Anat Embryol (2006) 211: 47–60.por
dc.identifier.doihttp://dx.doi.org/10.1007/s00429-005-0055-z
dc.identifier.issn0340-2061
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5480
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringer Verlagpor
dc.subjectFlatfishpor
dc.subjectPituitarypor
dc.subjectThyroidpor
dc.subjectMetamorphosispor
dc.subjectHippoglossus hippoglossuspor
dc.titleThyroid and pituitary gland development from hatching through metamorphosis of a teleost flatfish, the Atlantic halibutpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage60por
oaire.citation.startPage47por
oaire.citation.titleAnatomy and Embryologypor
oaire.citation.volume211por
person.familyNameSilva
person.familyNamePower
person.givenNameNádia
person.givenNameDeborah Mary
person.identifier.ciencia-id5D1F-6F3A-A1C2
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-9881-4421
person.identifier.orcid0000-0003-1366-0246
person.identifier.scopus-author-id10244362100
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationa467188c-1363-4f77-a9a9-8297de10a01a
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

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