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Exploring Omega-3′s impact on the expression of Bone-Related Genes in Meagre (Argyrosomus regius)

2023-12-31Journal article Open Access
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dc.contributor.authorLuján-Amoraga, Leticia
dc.contributor.authorDelgado-Martín, Belén
dc.contributor.authorLourenço-Marques, Cátia
dc.contributor.authorJ. Gavaia, Paulo
dc.contributor.authorBravo, Jimena
dc.contributor.authorBandarra, Narcisa M.
dc.contributor.authorDominguez, David
dc.contributor.authorIzquierdo, Marisol S.
dc.contributor.authorPousão-Ferreira, Pedro
dc.contributor.authorRibeiro, Laura
dc.date.accessioned2024-01-30T13:16:31Z
dc.date.available2024-01-30T13:16:31Z
dc.date.issued2023-12-31
dc.date.updated2024-01-26T14:10:41Z
dc.description.abstractDietary supplementation with Omega-3 fatty acids seems to promote skeletal health. Therefore, their consumption at imbalanced or excessive levels has offered less beneficial or even prejudicial effects. Fish produced in aquaculture regimes are prone to develop abnormal skeletons. Although larval cultures are usually fed with diets supplemented with Omega-3 Long Chain Polyunsaturated fatty acids (LC-PUFAs), the lack of knowledge about the optimal requirements for fatty acids or about their impact on mechanisms that regulate skeletal development has impeded the design of diets that could improve bone formation during larval stages when the majority of skeletal anomalies appear. In this study, Argyrosomus regius larvae were fed different levels of Omega-3s (2.6% and 3.6% DW on diet) compared to a commercial diet. At 28 days after hatching (DAH), their transcriptomes were analyzed to study the modulation exerted in gene expression dynamics during larval development and identify impacted genes that can contribute to skeletal formation. Mainly, both levels of supplementation modulated bone-cell proliferation, the synthesis of bone components such as the extracellular matrix, and molecules involved in the interaction and signaling between bone components or in important cellular processes. The 2.6% level impacted several genes related to cartilage development, denoting a special impact on endochondral ossification, delaying this process. However, the 3.6% level seemed to accelerate this process by enhancing skeletal development. These results offered important insights into the impact of dietary Omega-3 LC-PUFAs on genes involved in the main molecular mechanism and cellular processes involved in skeletal development.pt_PT
dc.description.sponsorshipEuropean Union’s Horizon 2020; MAR-02.01.01-FEAMP-0175; Grant 2021/04870/BDpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBiomolecules 14 (1): 56 (2024)pt_PT
dc.identifier.doi10.3390/biom14010056pt_PT
dc.identifier.eissn2218-273X
dc.identifier.urihttp://hdl.handle.net/10400.1/20324
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAquaculture meets Biomedicine: Innovation in Skeletal Health research.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFish larvaept_PT
dc.subjectSkeletal developmentpt_PT
dc.subjectDifferentially expressed genespt_PT
dc.subjectCartilagept_PT
dc.titleExploring Omega-3′s impact on the expression of Bone-Related Genes in Meagre (Argyrosomus regius)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAquaculture meets Biomedicine: Innovation in Skeletal Health research.
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/766347/EU
oaire.citation.issue1pt_PT
oaire.citation.startPage56pt_PT
oaire.citation.titleBiomoleculespt_PT
oaire.citation.volume14pt_PT
oaire.fundingStreamH2020
person.familyNameGavaia
person.givenNamePaulo
person.identifier.ciencia-idB619-FC16-D007
person.identifier.orcid0000-0002-9582-1957
person.identifier.ridA-6470-2011
person.identifier.scopus-author-id6507104377
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9dca2139-21a4-4d59-aaf7-531f1033a58e
relation.isAuthorOfPublication.latestForDiscovery9dca2139-21a4-4d59-aaf7-531f1033a58e
relation.isProjectOfPublication29e15538-1493-4e61-8be8-055155b79344
relation.isProjectOfPublication.latestForDiscovery29e15538-1493-4e61-8be8-055155b79344

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