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Vanadate oligomer inhibition of passive and active Ca2+ translocation by the Ca2+ pump of sarcoplasmic reticulum
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‘Monovanadate’ containing mainly monomeric, dimeric and tetrameric vanadate species or ‘decavanadate’, containingmainlydecameric
vanadate species inhibits the passive and the active efflux of Ca2+ through the sarcoplasmic reticulum calcium pump. When the efflux of Ca2+ by sarcoplasmic reticulum vesicles is not associated with ATP synthesis both vanadate solutions inhibit the passive efflux of Ca 2+.
However, only ‘decavanadate’ exerts noticeable effects when the efflux of Ca2q is associated with ATP synthesis being the active efflux of Ca2+ almost completely inhibited by decameric species concentration as low as 40 microM.
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Decavanadate Calcium ATPase Sarcoplasmic reticulum