Characterization of specific antibodies for fish osteocalcin and its usefulness to investigate osteocalcin tissue distribution in lower vertebrates.

Simes, D; Gavaia, Paulo J.; Ortiz-Delgado, J. B.; Pinto, Jorge; Cancela, Leonor

http://hdl.handle.net/10400.1/4426

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Abstract(s)

Osteocalcin (BGP or Bone Gla protein) is a small acidic protein with 46-50 residues (pI»4.0) that belongs to the family of the vitamin K dependent, Gla containing proteins. This protein is the most abundant non-collagenous bone protein in mammals and has been isolated only from bone and dentine suggesting that it may be expressed only in hydroxyapatite-containing bone tissue. Previous studies suggest that in mammals BGP is an ossification regulator, but its mode of action at the molecular level, in particular in non-mammalian organisms, remains unclear

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http://hdl.handle.net/10400.1/4426

Citation

Simes, D.C., Gavaia, P.J., Pinto, J.P., Cancela, M.L. 2001. Characterization of specific antibodies for fish osteocalcin and its usefulness to investigate osteocalcin tissue distribution in lower vertebrates. Bone, 28 (5) S103, P10.