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Does vitamin D supplementation impact serotonin levels? A systematic review and meta-analysis.

2024-08Journal article Open Access
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dc.contributor.authorAlimohammadi-Kamalabadi, Malek
dc.contributor.authorZiaei, Somayeh
dc.contributor.authorHasani, Motahareh
dc.contributor.authorMohammadi, Shooka
dc.contributor.authorMehrbod, Milad
dc.contributor.authorMorvaridi, Mehrnaz
dc.contributor.authorPersad, Emma
dc.contributor.authorBelančić, Andrej
dc.contributor.authorMalekahmadi, Mahsa
dc.contributor.authorEstêvão, Maria Dulce da Mota Antunes de Oliveira
dc.contributor.authorDaneshzad, Elnaz
dc.contributor.authorHeshmati, Javad
dc.date.accessioned2024-11-20T14:07:39Z
dc.date.available2024-11-20T14:07:39Z
dc.date.issued2024-08
dc.description.abstractVitamin D deficiency impacts a significant proportion of the world's population, and this deficiency has been linked to various conditions characterized by imbalanced serotonin regulation. The objective of this systematic review and meta-analysis was to evaluate the effect of vitamin D supplementation on serum serotonin levels. We conducted a comprehensive search of PubMed, Scopus, Cochrane Central for Randomized Clinical Trials, and Web of Science up to September 2022, without any language restrictions. The effect sizes were calculated using the standard mean difference (SMD) and 95% confidence interval (CI). Six randomized clinical trials involving 356 participants were included in the analysis. Our findings indicated no significant changes in serotonin levels between the intervention and control groups (SMD: 0.24 ng/mL, 95% CI: -0.28, 0.75,  > 0.10). Subgroup analysis also did not reveal any significant changes in serotonin levels among children, participants with autism spectrum disorders, interventions lasting 10 weeks or longer, or those receiving vitamin D doses below 4000 IU/day. Although the results obtained in this systematic review are inconclusive, they support the need for further well-designed randomized trials to assess the potential role of vitamin D supplementation in regulating serotonin levels and potentially ameliorating depression and related disorders.eng
dc.identifier.doi10.1002/hsr2.2276
dc.identifier.issn2398-8835
dc.identifier.other39086509
dc.identifier.urihttp://hdl.handle.net/10400.1/26310
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject5‐HT
dc.subjectCholecalciferol
dc.subjectMeta‐Analysis
dc.subjectSerotonin
dc.subjectSystematic Review
dc.subjectVitamin D
dc.titleDoes vitamin D supplementation impact serotonin levels? A systematic review and meta-analysis.eng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8
oaire.citation.startPagee2276
oaire.citation.titleHealth Science Reports
oaire.citation.volume7
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameEstêvão
person.givenNameMaria Dulce da Mota Antunes de Oliveira
person.identifierI-4695-2014
person.identifier.ciencia-id881B-53E8-0DB1
person.identifier.orcid0000-0002-7151-8363
person.identifier.scopus-author-id8381590400
relation.isAuthorOfPublication67887883-2695-48cc-8221-aa46780ac143
relation.isAuthorOfPublication.latestForDiscovery67887883-2695-48cc-8221-aa46780ac143

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