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PACAP, VIP and their receptors in the metazoa Insights about the origin and evolution of the ligand-receptor pair

2007Journal article Restricted access
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dc.contributor.authorCardoso, J. C. R.
dc.contributor.authorVieira, Florbela A.
dc.contributor.authorPower, Deborah
dc.date.accessioned2014-10-24T10:28:37Z
dc.date.available2014-10-24T10:28:37Z
dc.date.issued2007
dc.description.abstractThe evolution, function and interaction of ligand–receptor pairs are of major pharmaceutical interest. Comparative sequence analysis approaches using data from phylogenetically distant organisms can provide insights into their origin and possible physiological roles. The present review focuses on the pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal polypeptide (VIP) and their receptors in the metazoa. A PACAP-like peptide is present in tunicates and chordates while VIP- and PACAP/VIP-specific receptors have only been isolated in the latter phyla. The apparently disparate evolution of the ligands and their specific receptors raises questions about their evolution during the metazoan radiation and also about how the ligands may have acquired new functions.por
dc.description.sponsorshipThis work was co-financed by POCI 2010 and the European social funds attributed by the Portuguese National Science Foundation (FCT) to project (POCI/CVT/61052/2004) and CCMAR Pluriannual project and a Post-doctoral (BPD/14449/2003) and PhD fellowship (BD/17630/2004) to JCRC and FV, respectively.por
dc.identifier.citationJoão C.R. Cardoso, Florbela A. Vieira, Ana S. Gomes, Deborah M. Power, "PACAP, VIP and their receptors in the metazoa Insights about the origin and evolution of the ligand-receptor pair" in Peptides 28 (2007), pp. 1902-1919.por
dc.identifier.doihttp://dx.doi.org/10.1016/j.peptides.2007.05.016
dc.identifier.issn0196-9781
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5461
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectEvolutionpor
dc.subjectGPCRspor
dc.subjectLigand–receptorpor
dc.subjectMetazoanpor
dc.subjectPACAPpor
dc.subjectVIPpor
dc.titlePACAP, VIP and their receptors in the metazoa Insights about the origin and evolution of the ligand-receptor pairpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1919por
oaire.citation.issue9por
oaire.citation.startPage1902por
oaire.citation.titlePeptidespor
oaire.citation.volume28por
person.familyNameCardoso
person.familyNamePower
person.givenNameJoão
person.givenNameDeborah Mary
person.identifier14332
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication1b670c84-15e3-4776-8871-50f9eb0eed0d
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscovery1b670c84-15e3-4776-8871-50f9eb0eed0d

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