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Identification of androgen receptor variants in testis from humans and other vertebrates

dc.contributor.authorLaurentino, S. S.
dc.contributor.authorPinto, Patricia IS
dc.contributor.authorTomas, J.
dc.contributor.authorCavaco, J. E. B.
dc.contributor.authorSousa, M.
dc.contributor.authorBarros, A.
dc.contributor.authorPower, Deborah
dc.contributor.authorCanario, Adelino V. M.
dc.contributor.authorSocorro, S.
dc.date.accessioned2014-05-12T10:39:41Z
dc.date.available2014-05-12T10:39:41Z
dc.date.issued2013
dc.date.updated2014-05-08T09:38:19Z
dc.description.abstractThe androgen receptor (AR) is a ligand-activated transcription factor member of the nuclear receptor superfamily. The existence of alternatively spliced variants is well recognised for several members of this superfamily, most of them having functional importance. For example, several testicular oestrogen receptor variants have been suggested to play a role in the regulation of spermatogenesis. However, information on AR variants is mostly related to cancer and androgen insensitivity syndrome (AIS) cases. The objective of this study was to investigate the expression of AR variants in the testis from humans and other vertebrates. Four AR variants [ARD2Stop, ARD223Stop, ARD3 and ARD4(120)] were identified in human testis. ARD2Stop and ARD3, with exon 2 or 3 deleted, respectively, were also expressed in human liver, lung, kidney and heart. In addition, ARD2Stop was expressed in rat and gilthead seabream testis, while an ARD3 was detected in African clawed frog testis. This is the first report revealing the existence of AR variants in the testis of evolutionarily distant vertebrate species and in nonpathological tissues. These data suggest the functional importance of these novel AR forms and demonstrate a complexity in AR signalling that is not exclusive of pathological conditions.por
dc.identifier.citationLaurentino, S. S.; Pinto, P. I. S.; Tomas, J.; Cavaco, J. E. B.; Sousa, M.; Barros, A.; Power, D. M.; Canario, A. V. M.; Socorro, S. Identification of androgen receptor variants in testis from humans and other vertebrates, Andrologia, 45, 3, 187-194, 2013.por
dc.identifier.doihttp://dx.doi.org/10.1111/j.1439-0272.2012.01333.x
dc.identifier.issn0303-4569
dc.identifier.otherAUT: DPO00386; ACA00258;
dc.identifier.urihttp://hdl.handle.net/10400.1/3861
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.subjectAlternative splicingpor
dc.subjectVariantspor
dc.subjectTranscriptspor
dc.subjectSparus auratuspor
dc.subjectAndrogen receptorpor
dc.titleIdentification of androgen receptor variants in testis from humans and other vertebratespor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage194por
oaire.citation.issue3por
oaire.citation.startPage187por
oaire.citation.titleAndrologiapor
oaire.citation.volume45por
person.familyNamePinto
person.familyNamePower
person.familyNameCanario
person.givenNamePatricia IS
person.givenNameDeborah Mary
person.givenNameAdelino
person.identifier643457
person.identifier143624
person.identifier.ciencia-idE51D-5CCB-B1C6
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0001-7854-3898
person.identifier.orcid0000-0003-1366-0246
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridM-3817-2013
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id10240774300
person.identifier.scopus-author-id7101806760
person.identifier.scopus-author-id56568523700
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication64bc526e-5281-44e5-91eb-5743436109f9
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

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