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The goitrogenic efficiency of thioamides in a marine teleost, sea bream (Sparus auratus)

2012Journal article Restricted access
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dc.contributor.authorCampinho, Marco António
dc.contributor.authorMorgado, Isabel
dc.contributor.authorPinto, Patricia IS
dc.contributor.authorSilva, Nádia
dc.contributor.authorPower, Deborah
dc.date.accessioned2014-10-24T10:44:21Z
dc.date.available2014-10-24T10:44:21Z
dc.date.issued2012
dc.description.abstractStudies on the role of thyroid hormones (THs) in teleost fish physiology have deployed the synthetic goitrogens, methimazol (MMI), propilthiouracil (PTU) and thiourea (TU) that are used to treat human hyperthyroidism. However, the action of the goitrogens, MMI, PTU and TU at different levels of the hypothalamic–pituitary–thyroid (HPT) axis in teleosts is largely unknown. The central importance of the hypothalamus and pituitary in a number of endocrine regulated systems and the cross-talk that occurs between different endocrine axes makes it pertinent to characterize the effects of MMI, PTU and TU, on several endpoints of the thyroid system. The marine teleost, sea bream (Sparus auratus) was exposed to MMI, PTU and TU (1 mg/kg wet weight per day), via the diet for 21 days. Radioimmunoassays (RIA) of plasma THs and ELISA of the TH carrier transthyretin (TTR) revealed that MMI was the only chemical that significantly reduced plasma TH levels (p < 0.05), although both MMI and PTU significantly (p < 0.05) reduced plasma levels of circulating TTR (p < 0.05). Histological analysis of the thyroid tissue revealed modifications in thyrocyte activity that explain the reduced circulating levels of THs. MMI also significantly (p < 0.05) up-regulated transcript abundance of liver deiodinase 1 and 2 while significantly (p < 0.05) decreasing TRb expression in the pituitary, all hallmarks of HPT axis action of goitrogens in vertebrates. The results indicate that in the sea bream MMI is the most effective goitrogen followed by PTU and that TU (1 mg/kg wet weight for 21 days) failed to have a goitrogenic effect. The study highlights the non-uniform effect of goitrogens on the thyroid axis of sea bream and provides the basis for future studies of thyroid disrupting pollutants.por
dc.description.sponsorshipThis work was funded by the Portuguese Science Foundation through Grants SFRH/BPD/66808/2009 to MA Campinho and SFRH/BPD/25247/2005 to PIS Pinto. We acknowledge Alejandro Pinzon for his contribution in preliminary studies.por
dc.identifier.citationM.A. Campinho, I. Morgado, P.I.S. Pinto, N. Silva, D.M. Power, "The goitrogenic efficiency of thioamides in a marine teleost, sea bream (Sparus auratus)" in General and Comparative Endocrinology 179 (2012) 369–375.por
dc.identifier.doihttp://dx.doi.org/10.1016/j.ygcen.2012.09.022
dc.identifier.issn0016-6480
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5466
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectThioamidespor
dc.subjectDeiodinasespor
dc.subjectGoitrogenspor
dc.subjectSeabreampor
dc.subjectThyroid hormonespor
dc.subjectThyroid receptorspor
dc.titleThe goitrogenic efficiency of thioamides in a marine teleost, sea bream (Sparus auratus)por
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage375por
oaire.citation.startPage369por
oaire.citation.titleGeneral and Comparative Endocrinologypor
oaire.citation.volume179por
person.familyNameCampinho
person.familyNameMorgado
person.familyNamePinto
person.familyNameSilva
person.familyNamePower
person.givenNameMarco António
person.givenNameIsabel
person.givenNamePatricia IS
person.givenNameNádia
person.givenNameDeborah Mary
person.identifier643457
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person.identifier.ciencia-id3315-7715-C3B4
person.identifier.ciencia-idE51D-5CCB-B1C6
person.identifier.ciencia-id5D1F-6F3A-A1C2
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-5238-0506
person.identifier.orcid0000-0002-7826-997X
person.identifier.orcid0000-0001-7854-3898
person.identifier.orcid0000-0001-9881-4421
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridD-8833-2013
person.identifier.ridJ-4798-2013
person.identifier.ridM-3817-2013
person.identifier.scopus-author-id8938999600
person.identifier.scopus-author-id18134268300
person.identifier.scopus-author-id10240774300
person.identifier.scopus-author-id10244362100
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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