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PACAP system evolution and its role in melanophore function in teleost fish skin

2015Journal article Open access
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dc.contributor.authorCR Cardoso, Joao
dc.contributor.authorC. Félix, Rute
dc.contributor.authorMartins, Rute
dc.contributor.authorM., Trindade
dc.contributor.authorG Fonseca, Vera
dc.contributor.authorFuentes, Xoan
dc.contributor.authorPower, Deborah
dc.date.accessioned2020-07-31T14:16:59Z
dc.date.available2020-07-31T14:16:59Z
dc.date.issued2015
dc.description.abstractPituitary adenylate cyclase-activating polypeptide (PACAP) administered to tilapia melanophores ex-vivo causes significant pigment aggregation and this is a newly identified function for this peptide in fish. The G-protein coupled receptors (GPCRs), adcyap1r1a (encoding Pac1a) and vipr2a (encoding Vpac2a), are the only receptors in melanophores with appreciable levels of expression and are significantly (p < 0.05) down-regulated in the absence of light. Vpac2a is activated exclusively by peptide histidine isoleucine (PHI), which suggests that Pac1a mediates the melanin aggregating effect of PACAP on melanophores. Paradoxically activation of Pac1a with PACAP caused a rise in cAMP, which in fish melanophores is associated with melanin dispersion. We hypothesise that the duplicate adcyap1ra and vipr2a genes in teleosts have acquired a specific role in skin and that the melanin aggregating effect of PACAP results from the interaction of Pac1a with Ramp that attenuates cAMP-dependent PKA activity and favours the Ca(2+)/Calmodulin dependent pathway.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.mce.2015.04.020pt_PT
dc.identifier.issn0303-7207
dc.identifier.urihttp://hdl.handle.net/10400.1/14563
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectBiological evolutionpt_PT
dc.subjectDatabasespt_PT
dc.subjectMelanophorespt_PT
dc.subjectPhylogenypt_PT
dc.subjectPituitary Adenylate Cyclase-Activating Polypeptide (PACAP)pt_PT
dc.subjectSkinpt_PT
dc.subjectTilapiapt_PT
dc.subjectFactualpt_PT
dc.titlePACAP system evolution and its role in melanophore function in teleost fish skinpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage145pt_PT
oaire.citation.startPage130pt_PT
oaire.citation.titleMolecular and Cellular Endocrinologypt_PT
oaire.citation.volume411pt_PT
person.familyNameCardoso
person.familyNameFélix
person.familyNameMartins
person.familyNameTrindade
person.familyNameFonseca
person.familyNameFuentes
person.familyNamePower
person.givenNameJoão
person.givenNameRute
person.givenNameRute Sofia Tavares
person.givenNameMarlene
person.givenNameVera
person.givenNameJuan
person.givenNameDeborah Mary
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person.identifier.orcid0000-0003-1021-7003
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person.identifier.ridM-4151-2013
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person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id56006773000
person.identifier.scopus-author-id36058658400
person.identifier.scopus-author-id7201832526
person.identifier.scopus-author-id7101806760
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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