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Nanopartículas de ouro para diagnóstico e tratamento de cancro
| Name: | Description: | Size: | Format: | |
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| 1.89 MB | Adobe PDF |
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Abstract(s)
As nanopartículas de ouro têm se apresentado como uma ferramenta com potencial em diversas aplicações na nanomedicina devido às suas características únicas como baixa toxicidade, elevada área superficial e biodisponibilidade.
Estes materiais podem ser preparados através de diversas técnicas de forma a apresentarem as características estruturais e morfológicas pretendidas e, consequentemente, o comportamento pretendido. Após a preparação, as nanopartículas de ouro podem ser funcionalizadas com diversos compostos e/ou fármacos de forma a alterar as suas características e o seu comportamento. Estas alterações podem melhorar os resultados na terapêutica anticancerígena ao aumentar a eficácia do tratamento e ao reduzir os efeitos adversos que estas podem causar.
A caracterização das nanopartículas de ouro é um parâmetro complexo e essencial para a compreensão das características e do comportamento das partículas. São vários os métodos de caracterização que podem ser utilizados e a escolha dos métodos a utilizar deve ser a considerada mais adequada para uma mais eficaz caracterização.
As nanopartículas de ouro podem ser utilizadas em diversos métodos de tratamento e de diagnóstico de cancro. Como meio de diagnóstico, têm utilidade em diversos processos de obtenção de imagem de tecidos tumorais. Como método de tratamento de cancro, estas podem ser utilizadas como meio de transporte de fármacos, em radioterapia, em terapia fototérmica e fotodinâmica.
Nesta monografia, é feita uma revisão e descrição dos métodos de síntese mais utilizados das nanopartículas de ouro, da funcionalização da superfície e da caracterização das nanopartículas de ouro. É também feita a revisão e descrição das nanopartículas de ouro e das suas potenciais aplicações no cancro, tanto como meio de diagnóstico como método de tratamento
Gold nanoparticles have emerged as a potential tool with diverse applications in nanomedicine due to their unique characteristics such as low toxicity, high surface area and bioavailability. These materials can be prepared using different techniques to present the desired structural and morphological characteristics and, consequently, the desired behavior. After preparation, gold nanoparticles can be functionalized with various compounds and/or drugs to change their characteristics and behavior. These changes can improve results in anticancer therapy by increasing the effectiveness of treatment and reducing the adverse effects they can cause. The characterization of gold nanoparticles is a complex and essential parameter for understanding the characteristics and behavior of the particles. There are several characterization methods that can be used and the choice of methods to be used must be the one considered most appropriate for a more effective characterization. Gold nanoparticles can be used in various cancer treatment and diagnosis methods. As a means of diagnosis, they are useful in various processes for obtaining images of tumor tissues. As a method of treating cancer, they can be used as a means of transporting drugs, in radiotherapy, in photothermal and photodynamic therapy. In this monograph, a review and description of the most used synthesis methods for gold nanoparticles, surface functionalization and characterization of gold nanoparticles are made. Gold nanoparticles and their potential applications in cancer are also reviewed and described, both as a means of diagnosis and a method of treatment.
Gold nanoparticles have emerged as a potential tool with diverse applications in nanomedicine due to their unique characteristics such as low toxicity, high surface area and bioavailability. These materials can be prepared using different techniques to present the desired structural and morphological characteristics and, consequently, the desired behavior. After preparation, gold nanoparticles can be functionalized with various compounds and/or drugs to change their characteristics and behavior. These changes can improve results in anticancer therapy by increasing the effectiveness of treatment and reducing the adverse effects they can cause. The characterization of gold nanoparticles is a complex and essential parameter for understanding the characteristics and behavior of the particles. There are several characterization methods that can be used and the choice of methods to be used must be the one considered most appropriate for a more effective characterization. Gold nanoparticles can be used in various cancer treatment and diagnosis methods. As a means of diagnosis, they are useful in various processes for obtaining images of tumor tissues. As a method of treating cancer, they can be used as a means of transporting drugs, in radiotherapy, in photothermal and photodynamic therapy. In this monograph, a review and description of the most used synthesis methods for gold nanoparticles, surface functionalization and characterization of gold nanoparticles are made. Gold nanoparticles and their potential applications in cancer are also reviewed and described, both as a means of diagnosis and a method of treatment.
Description
Keywords
Cancro Nanopartículas Ouro Funcionalização Terapia Diagnóstico