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Chemical composition, antioxidant, and α-Glucosidase-Inhibiting activity of aqueous and hydroethanolic extracts of traditional antidiabetics from croatian ethnomedicine
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Advisor(s)
Abstract(s)
Type 2 diabetes (T2D) is a chronic disease with a growing prevalence worldwide. In
addition to the conventional therapy, many T2D patients use phytotherapeutic preparations. In the
present study, chemical composition, antioxidant, and -glucosidase inhibiting activity of traditional
antidiabetics from Croatian ethnomedicine (Achillea millefolium, Artemisia absinthium, Centaurium
erythraea, Morus alba, Phaseolus vulgaris, Sambucus nigra, and Salvia officinalis) were assessed. The
efficacy of water and 80% ethanol as extraction solvents for bioactive constituents was compared.
HPLC analysis revealed that the prepared extracts were rich in phenols, especially rutin, ferulic,
and chlorogenic acid. Antiradical (against DPPH and ABTS radicals), reducing (towards Mo6+ and
Fe3+ ions), and enzyme inhibiting properties were in linear correlation with the content of phenolic
constituents. Ethanolic extracts, richer in phenolic substances, showed dominant efficacy in those
assays. Aqueous extracts, on the other hand, were better Fe2+ ion chelators and more active in the
-carotene linoleic acid assay. Extracts from S. officinalis and A. millefolium were particularly active
antioxidants and -glucosidase inhibitors. A. absinthium, another potent -glucosidase inhibitor,
contained chromium, a mineral that promotes insulin action. The investigated plants contained
significant amounts of minerals useful in management of T2D, with negligible amounts of heavy
metals deeming them safe for human use.
Description
Keywords
Chromium Natural antioxidants Ethnopharmacology Polyphenol Flavonoids Glucose-lowering activity HPLC
Citation
Publisher
MDPI