Repository logo
 
Publication

Nanocomposite sponges for enhancing intestinal residence time following oral administration

2021Journal article Restricted access
Simple item page
dc.contributor.authorRosso, Annalisa
dc.contributor.authorAndretto, Valentina
dc.contributor.authorChevalier, Yves
dc.contributor.authorKryza, David
dc.contributor.authorSidi-Boumedine, Jacqueline
dc.contributor.authorGrenha, Ana
dc.contributor.authorGuerreiro, Filipa
dc.contributor.authorGharsallaoui, Adem
dc.contributor.authorLa Padula, Veronica
dc.contributor.authorMontembault, Alexandra
dc.contributor.authorDavid, Laurent
dc.contributor.authorBriançon, Stéphanie
dc.contributor.authorLollo, Giovanna
dc.date.accessioned2021-06-30T13:33:29Z
dc.date.available2021-06-30T13:33:29Z
dc.date.issued2021
dc.description.abstractIn this work, nanocomposites that combine mucopenetrating and mucoadhesive properties in a single system are proposed as innovative strategy to increase drug residence time in the intestine following oral administration. To this aim, novel mucoadhesive chitosan (CH) sponges loaded with mucopenetrating nanoemulsions (NE) were developed via freeze-casting technique. The NE mucopenetration ability was determined studying the surface affinity and thermodynamic binding of the nanosystem with mucins. The ability of nanoparticles to penetrate across a preformed mucins layer was validated by 3D-time laps Confocal Laser Scanning Microscopy imaging. Microscopy observations (Scanning Electron Microscopy and Optical Microscopy) showed that NE participated in the structure of the sponge affecting its stability and in vitro release kinetics. When incubated with HCT 116 and Caco-2 cell lines, the NE proved to be cytocompatible over a wide concentration range. Finally, the in vivo biodistribution of the nanocomposite was evaluated after oral gavage in healthy mice. The intestinal retention of NE was highly enhanced when loaded in the sponge compared to the NE suspension. Overall, our results demonstrated that the developed nanocomposite sponge is a promising system for sustained drug intestinal delivery.pt_PT
dc.description.sponsorshipPortuguese Foundati on for Science and Technology and European Commission: 42306YB; Portuguese Foundation for Science and Technology: UID/Multi/04326/2020pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jconrel.2021.04.004pt_PT
dc.identifier.issn0168-3659
dc.identifier.urihttp://hdl.handle.net/10400.1/16685
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNanocompositept_PT
dc.subjectNanoemulsionpt_PT
dc.subjectChitosan spongept_PT
dc.subjectOral administrationpt_PT
dc.subjectIntestinal drug deliverypt_PT
dc.titleNanocomposite sponges for enhancing intestinal residence time following oral administrationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage592pt_PT
oaire.citation.startPage579pt_PT
oaire.citation.titleJournal of Controlled Releasept_PT
oaire.citation.volume333pt_PT
person.familyNameGrenha
person.familyNameGuerreiro
person.givenNameAna
person.givenNameFilipa
person.identifier.ciencia-id091C-0D58-7225
person.identifier.ciencia-idBF1D-7EFA-19BC
person.identifier.orcid0000-0002-2136-1396
person.identifier.orcid0000-0001-6224-1553
person.identifier.ridH-1392-2017
person.identifier.scopus-author-id8607930100
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d
relation.isAuthorOfPublicationb88abfe8-e32c-477f-9fb0-5bdeca8a1a05
relation.isAuthorOfPublication.latestForDiscovery1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Rosso et al. 2021.pdf
Size:
3.02 MB
Format:
Adobe Portable Document Format
Download

Collections

CCM2-Artigos (em revistas ou actas indexadas)