Publication
LC-HRMS profiling of paralytic shellfish toxins in Mytilus galloprovincialis after a Gymnodinium catenatum bloom
| dc.contributor.author | Lage, Sandra | |
| dc.contributor.author | Reis Costa, Pedro | |
| dc.contributor.author | Canario, Adelino | |
| dc.contributor.author | Da Silva, José Paulo | |
| dc.date.accessioned | 2022-11-12T10:52:41Z | |
| dc.date.available | 2022-11-12T10:52:41Z | |
| dc.date.issued | 2022-10-28 | |
| dc.date.updated | 2022-11-10T14:28:05Z | |
| dc.description.abstract | Saxitoxin and its more than 50 analogues are a group of naturally occurring neurotoxins collectively designated as paralytic shellfish toxins (PSTs). PSTs are toxic to humans and maximum legal limits in seafood have been implemented by regulatory authorities worldwide. In the European Union, monitoring of PSTs is performed using the AOAC Official Method 2005.06, based on liquid chromatography coupled with fluorescence detection (LC- FLD). However, this method has been suggested to not effectively detect the emerging C-11 hydroxyl (M-toxins) and benzoate (GC-toxins) analogues, with these analogues currently not being surveyed in monitoring programs. In this study, a liquid chromatography-high resolution mass spectrometry (LC-HRMS) method was used to search for these emerging PSTs in mussels, Mytilus galloprovincialis, contaminated following an intense Gymnodinium catenatum bloom in the Tagus estuary (Lisbon, Portugal). Five M-toxins (M1, M2, M6, dcM6, and dcM10), but no GC-toxins, were detected in the mussels’ whole-soft body tissue. Moreover, the classical PSTs (C1 to C4, GTX 4 to GTX6, dcGTX1 to dcGTX4, dcSTX, dcNEO, and STX) were also found and comprised the largest fraction of the PSTs’ profile. The presence of unregulated PSTs in edible mussel samples suggests potential seafood safety risks and urges further research to determine the frequency of these analogues in seafood and their contribution to toxicity | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Marine Drugs 20 (11): 680 (2022) | pt_PT |
| dc.identifier.doi | 10.3390/md20110680 | pt_PT |
| dc.identifier.eissn | 1660-3397 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/18501 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation | LA/P/0101/2020; CRESC Algarve 2020; COMPETE 2020; EMBRC.PT ALG-01-0145-FEDER-022121 | |
| dc.relation | Algarve Centre for Marine Sciences | |
| dc.relation | Algarve Centre for Marine Sciences | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | M-toxins | pt_PT |
| dc.subject | GC-toxins | pt_PT |
| dc.subject | Gymnodinium catenatum | pt_PT |
| dc.subject | Marine biotoxins | pt_PT |
| dc.subject | Emergent toxin | pt_PT |
| dc.subject | Seafood safety | pt_PT |
| dc.subject | Occurrence data | pt_PT |
| dc.subject | European waters | pt_PT |
| dc.subject | Shellfish poisoning | pt_PT |
| dc.subject | LC-HRMS | pt_PT |
| dc.title | LC-HRMS profiling of paralytic shellfish toxins in Mytilus galloprovincialis after a Gymnodinium catenatum bloom | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Algarve Centre for Marine Sciences | |
| oaire.awardTitle | Algarve Centre for Marine Sciences | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT | |
| oaire.citation.issue | 11 | pt_PT |
| oaire.citation.startPage | 680 | pt_PT |
| oaire.citation.title | Marine Drugs | pt_PT |
| oaire.citation.volume | 20 | pt_PT |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | Lage | |
| person.familyName | Reis Costa | |
| person.familyName | Canario | |
| person.familyName | Silva | |
| person.givenName | Sandra | |
| person.givenName | Pedro | |
| person.givenName | Adelino | |
| person.givenName | José Paulo da | |
| person.identifier | 454970 | |
| person.identifier | 600820 | |
| person.identifier | 143624 | |
| person.identifier.ciencia-id | DA15-C119-BDC8 | |
| person.identifier.ciencia-id | C911-9715-E547 | |
| person.identifier.ciencia-id | 1F1E-D3B3-F804 | |
| person.identifier.ciencia-id | 3413-C4F4-73F7 | |
| person.identifier.orcid | 0000-0003-0167-7163 | |
| person.identifier.orcid | 0000-0001-6083-470X | |
| person.identifier.orcid | 0000-0002-6244-6468 | |
| person.identifier.orcid | 0000-0002-6458-7328 | |
| person.identifier.rid | N-1908-2019 | |
| person.identifier.rid | C-7942-2009 | |
| person.identifier.rid | A-4606-2008 | |
| person.identifier.scopus-author-id | 54585529500 | |
| person.identifier.scopus-author-id | 7201895802 | |
| person.identifier.scopus-author-id | 56568523700 | |
| person.identifier.scopus-author-id | 7201733236 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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