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Effects of mixtures of anticancer drugs in the benthic polychaete Nereis diversicolor

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dc.contributor.authorFonseca, Tainá
dc.contributor.authorAbessa, Denis M. S.
dc.contributor.authorBebianno, Maria João
dc.date.accessioned2020-04-03T15:16:15Z
dc.date.available2020-04-03T15:16:15Z
dc.date.issued2019
dc.description.abstractThe increasing consumption of anticancer drugs through single and/or combinatory chemotherapy worldwide raised concern regarding their toxicity burden in coastal zones. The toxicity of a mixture of three compounds involving the drugs cisplatin (CisPt), cyclophosphamide (CP) and tamoxifen (TAM) was determined on the marine polychaete Nereis diversicolor exposed to an increasing range of their concentrations, respectively: Mix A: 0.1 + 10 + 0.1 ng L-1; Mix B: 10 + 100 + 10 ng L-1; Mix C: 100 + 500 + 25 ng L-1; Mix D: 100 + 1000 + 100 ng L-1. Different endpoints were assessed, including disturbance in the burrowing behaviour, neurotoxicity (acetylcholinesterase - AChE activity), antioxidant enzymes (superoxide dismutase - SOD; catalase - CAT; selenium-dependent glutathione peroxidase - Se-GPx and total glutathione peroxidases T-GPx activities), biotransformation metabolism (glutathione-S-transferases - GST), lipid peroxidation (LPO) and genotoxicity (DNA damage). Biological effects of the mixtures of anticancer compounds on N. diversicolor were compared with previous studies about effects on the same biological model under single-drug exposure conducted with the same molecules. Regarding SOD activity, TAM showed an antagonist effect over CisPt and CP in mixtures C and D. In Mix D, there was a synergistic effect of TAM and CisPt that inhibited CAT activity and an additive interaction of CisPt and CP on the Phase II biotransformation enzyme. Drugs in Mix A also suppressed polychaetes' GST activity, although different from the respective single-drug responses, besides able to induce T-GPx activity, that was not sufficient to avoid oxidative damage and mid-grade DNA damage. Due to the absence of burrowing impairment in Mix A, mechanisms involved in neurotoxicity were other than the one driven by AChE alterations. At the intermediary concentrations (Mix B and C), only LPO occurred. Data from drugs individually may not predict the risks provided by mixtures.pt_PT
dc.description.sponsorship202360/2014-8; 308533/2018-6; 311609/2014-7
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1016/j.envpol.2019.05.095pt_PT
dc.identifier.issn0269-7491
dc.identifier.urihttp://hdl.handle.net/10400.1/13687
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEfeitos de mixturas de contaminantes emergentes nos ecossistemas aquáticos: uma abordagem a vários níveis de organização biológica
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0269749118355064?via%3Dihubpt_PT
dc.subjectAcetylcholinesterasept_PT
dc.subjectAnimalspt_PT
dc.subjectAntineoplastic Agentspt_PT
dc.subjectAntioxidantspt_PT
dc.subjectBiotransformationpt_PT
dc.subjectCatalasept_PT
dc.subjectCyclophosphamidept_PT
dc.subjectDNA damagept_PT
dc.subjectGlutathione peroxidasept_PT
dc.subjectGlutathione transferasept_PT
dc.subjectLipid Peroxidationpt_PT
dc.subjectOxidative stresspt_PT
dc.subjectPolychaetapt_PT
dc.subjectSeleniumpt_PT
dc.subjectSuperoxide dismutasept_PT
dc.subjectWater pollutantspt_PT
dc.subjectChemicalpt_PT
dc.titleEffects of mixtures of anticancer drugs in the benthic polychaete Nereis diversicolorpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEfeitos de mixturas de contaminantes emergentes nos ecossistemas aquáticos: uma abordagem a vários níveis de organização biológica
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMAR%2F00350%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIA-BMA%2F30922%2F2017/PT
oaire.citation.endPage1192pt_PT
oaire.citation.issuePt Bpt_PT
oaire.citation.startPage1180pt_PT
oaire.citation.titleEnvironmental Pollutionpt_PT
oaire.citation.volume252pt_PT
oaire.fundingStream5876
oaire.fundingStream9471 - RIDTI
person.familyNameGARCIA DA FONSECA
person.familyNameBebianno
person.givenNameTAINÁ
person.givenNameMaria
person.identifier.ciencia-idCC10-4E47-B6DD
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery0bacd985-5b3b-4cc8-a31c-774ec234205f
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