Regulation of injury-induced neurogenesis by Nitric Oxide

Carreira, Bruno P.; Carvalho, Caetana M.; Araújo, Inês

http://hdl.handle.net/10400.1/12057

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Authors

Carreira, Bruno P.

Carvalho, Caetana M.

Araújo, Inês

Abstract(s)

The finding that neural stem cells (NSCs) are able to divide, migrate, and differentiate into several cellular types in the adult brain raised a new hope for restorative neurology. Nitric oxide (NO), a pleiotropic signaling molecule in the central nervous system (CNS), has been described to be able to modulate neurogenesis, acting as a pro-or antineurogenic agent. Some authors suggest that NO is a physiological inhibitor of neurogenesis, while others described NO to favor neurogenesis, particularly under inflammatory conditions. Thus, targeting the NO system may be a powerful strategy to control the formation of new neurons. However, the exact mechanisms by which NO regulates neural proliferation and differentiation are not yet completely clarified. In this paper we will discuss the potential interest of the modulation of the NO system for the treatment of neurodegenerative diseases or other pathological conditions that may affect the CNS.

Keywords

Focal cerebral-ischemia Central-nervous-system Neural precursor cells Necrosis-factor-alpha Rat dentate gyrus Nonsteroidal antiinflammatory drugs Subventricular zone neurogenesis Reduced hippocampal neurogenesis Growth-factor receptor Adult neurogenesis