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Regulation of injury-induced neurogenesis by Nitric Oxide

2012Journal article Open access
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dc.contributor.authorCarreira, Bruno P.
dc.contributor.authorCarvalho, Caetana M.
dc.contributor.authorAraújo, Inês
dc.date.accessioned2018-12-07T14:58:30Z
dc.date.available2018-12-07T14:58:30Z
dc.date.issued2012
dc.description.abstractThe finding that neural stem cells (NSCs) are able to divide, migrate, and differentiate into several cellular types in the adult brain raised a new hope for restorative neurology. Nitric oxide (NO), a pleiotropic signaling molecule in the central nervous system (CNS), has been described to be able to modulate neurogenesis, acting as a pro-or antineurogenic agent. Some authors suggest that NO is a physiological inhibitor of neurogenesis, while others described NO to favor neurogenesis, particularly under inflammatory conditions. Thus, targeting the NO system may be a powerful strategy to control the formation of new neurons. However, the exact mechanisms by which NO regulates neural proliferation and differentiation are not yet completely clarified. In this paper we will discuss the potential interest of the modulation of the NO system for the treatment of neurodegenerative diseases or other pathological conditions that may affect the CNS.
dc.description.sponsorshipFoundation for Science and Technology, (FCT, Portugal); COMPETE;
dc.identifier.doi10.1155/2012/895659
dc.identifier.issn1687-966X
dc.identifier.urihttp://hdl.handle.net/10400.1/12057
dc.language.isoeng
dc.peerreviewedyes
dc.publisherHindawi Publishing Corporation
dc.relationPHYSIOLOGICAL ROLE OF CALPAINS: HOW DO CALPAINS REGULATE CELL PROLIFERATION AND MIGRATION IN THE BRAIN
dc.subjectFocal cerebral-ischemia
dc.subjectCentral-nervous-system
dc.subjectNeural precursor cells
dc.subjectNecrosis-factor-alpha
dc.subjectRat dentate gyrus
dc.subjectNonsteroidal antiinflammatory drugs
dc.subjectSubventricular zone neurogenesis
dc.subjectReduced hippocampal neurogenesis
dc.subjectGrowth-factor receptor
dc.subjectAdult neurogenesis
dc.titleRegulation of injury-induced neurogenesis by Nitric Oxide
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePHYSIOLOGICAL ROLE OF CALPAINS: HOW DO CALPAINS REGULATE CELL PROLIFERATION AND MIGRATION IN THE BRAIN
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-NEU%2F102612%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F78901%2F2011/PT
oaire.citation.startPageUNSP 895659
oaire.citation.titleStem Cells International
oaire.fundingStream5876-PPCDTI
person.familyNamePombinho de Araújo
person.givenNameInês Maria
person.identifierF-4703-2012
person.identifier.ciencia-idD11F-D4CA-2947
person.identifier.orcid0000-0002-2438-0111
person.identifier.scopus-author-id56271084100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscovery1d0c21f4-0f4b-4589-8412-fe1079419774
relation.isProjectOfPublicationebe6962d-4dbe-4d72-ae51-fd3b4f05abb8
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relation.isProjectOfPublication.latestForDiscoveryebe6962d-4dbe-4d72-ae51-fd3b4f05abb8

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