Development and application of quality standard procedures ((operation,, verification and maintenance)) for an LC--MS system

Daniel, Christy Sarmiento

http://hdl.handle.net/10400.1/10741

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Authors

Daniel, Christy Sarmiento

Advisor(s)

Moyano, Encarnacion

Santos, Javier

Núñez, Oscar

Abstract(s)

In this work, the standard procedures required for the operation, verification and maintenance of a liquid chromatography coupled to mass spectrometry system have been developed. These procedures have been designed and prepared with the aim to establish a quality control system to ensure the proper functioning of each component of the instrumentation, the LC and the MS, and to verify the performance of the LC-MS coupling. For this purpose, standard procedures were elaborated and proved in the normal routine laboratory work to evaluate their real applicability. Moreover, the verification of the performance of the LC-MS system was carried out experimentally through an in-house procedure based on the analysis of naphthylacetics.