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Putative ancestral receptor genes of vertebrate family 2 GPCR in the invertebrate genome of the nematode Caenorhabditis elegans

2006Artigo científico Acesso restrito
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dc.contributor.authorCardoso, João CR
dc.contributor.authorVieira, Florbela A.
dc.contributor.authorClark, M. S.
dc.contributor.authorPower, Deborah
dc.date.accessioned2014-10-24T10:56:01Z
dc.date.available2014-10-24T10:56:01Z
dc.date.issued2006
dc.description.abstractThree putative ancestral genes for the family 2 of GPCRs were identified in the invertebrate genome of the nematode Caenorhabditis elegans (C. elegans). The nematode clones namely CB13B9.4, ZK643.3 and C18B12.2 are localised on chromosomes III (CB13B9.4, ZK643.3) and X (C18B12.2) and were identified by searching the nematode genome database with the amino acid sequences of the vertebrate family 2 receptor genes. In human and in the teleost Takifugu rubripes genomes, 15 and 21 members of the family 2 GPCRs have been identified, respectively. Linkage mapping analysis revealed that the gene environment of family 2 GPCRs is highly conserved between human and Takifugu genomes and some conservation also occurs with C. elegans chromosome III and X regions containing the putative family 2 GPCRs. Sequence comparative analysis revealed that the putative C. elegans receptors contained seven transmembrane (TM) domains and long N-terminal regions with conserved cysteine residues typical of the family 2 GPCR members. Phylogenetic analysis carried out with the TM domains of all vertebrate, chordate (Ciona) and insect (fruit fly) family 2 receptor members has shown that the nematode receptors identified tend to group with the clade containing the CRF and Calcitonin/CGRP family 2 GPCRs.por
dc.description.sponsorshipJ.C.R Cardoso is in receipt of a grant from FCT, Portugal (19925/99). The work was funded by CCMAR pluriannual grant and an MRC grant.por
dc.identifier.citationCardoso JCR, Vieira F, Clark MS and Power DM (2006) Putative ancestral receptor genes of vertebrate family 2 GPCR in the invertebrate genome of the nematode Caenorhabditis elegans. Journal of Experimental Zoology Part A-Comparative Experimental Biology 305A (2): 115-115por
dc.identifier.issn1548-8969
dc.identifier.otherAUT: DPO00386
dc.identifier.urihttp://hdl.handle.net/10400.1/5470
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.titlePutative ancestral receptor genes of vertebrate family 2 GPCR in the invertebrate genome of the nematode Caenorhabditis eleganspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage115por
oaire.citation.startPage115por
oaire.citation.titleJournal of Experimental Zoology Part A-Comparative Experimental Biologypor
oaire.citation.volume305Apor
person.familyNameCardoso
person.familyNamePower
person.givenNameJoão
person.givenNameDeborah Mary
person.identifier14332
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication1b670c84-15e3-4776-8871-50f9eb0eed0d
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscovery1b670c84-15e3-4776-8871-50f9eb0eed0d

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