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Intermittent hypoxia training remodels the hepatic mitochondrial network and upregulates ANT expression to enhance hypoxia tolerance in Micropterus salmoides

2026-10Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg14:Proteger a Vida Marinha
datacite.subject.sdg02:Erradicar a Fome
dc.contributor.authorLiu, Hao
dc.contributor.authorZhang, Dongmei
dc.contributor.authorHu, Yifan
dc.contributor.authorYan, Haoxiao
dc.contributor.authorLuo, Weizhe
dc.contributor.authorHe, Kuo
dc.contributor.authorZhang, Zhenghui
dc.contributor.authorYang, Hangyu
dc.contributor.authorPower, Deborah Mary
dc.contributor.authorCanario, Adelino
dc.contributor.authorLiu, Qiao
dc.contributor.authorYang, Song
dc.contributor.authorZhao, Liulan
dc.date.accessioned2026-05-07T13:44:12Z
dc.date.available2026-05-07T13:44:12Z
dc.date.issued2026-10
dc.description.abstractOxygen is critical for life, and aquatic organisms are especially susceptible to hypoxic stress caused by environmental fluctuations. However, the mechanisms underpinning their tolerance to hypoxia remain poorly understood. Largemouth bass (Micropterus salmoides) is widely distributed across a range of freshwater ecosystems and has significant economic and ecological value. Low oxygen has become a key limiting factor in the aquaculture of this species. This study examined the impact of intermittent hypoxia training (IHT) on hypoxia tolerance of largemouth bass by simulating the daily fluctuations in dissolved oxygen typical of natural aquatic environments. We found that IHT increased the hypoxic tolerance of largemouth bass by activating adenine nucleotide translocase (ANT) which mediated Ca2+ influx and cellular resistance to hypoxia. Inhibition of ANT compromised hypoxia tolerance by reducing hypoxia-induced mitochondrial Ca2+ accumulation and mitochondrial quality control. Additionally, ANT inhibition upregulated the expression of genes associated with oxidative stress and apoptosis. These findings highlight a key relationship between ANT and mitochondrial Ca2+ signaling in response to hypoxia, providing insights into the mechanism that enhances tolerance to hypoxia in largemouth bass.eng
dc.description.sponsorship2024NSFSC2069; 32403057; SCCXTD-2025-15
dc.identifier.doi10.1016/j.watbs.2025.100513
dc.identifier.issn2772-7351
dc.identifier.urihttp://hdl.handle.net/10400.1/28889
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.ispartofWater Biology and Security
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectANT
dc.subjectApoptosis
dc.subjectCalcium signal
dc.subjectHypoxia tolerance
dc.subjectIntermittent hypoxia training (IHT)
dc.subjectMicropterus salmoides
dc.subjectMitochondrial quality control
dc.titleIntermittent hypoxia training remodels the hepatic mitochondrial network and upregulates ANT expression to enhance hypoxia tolerance in Micropterus salmoideseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.startPage100513
oaire.citation.titleWater Biology and Security
oaire.citation.volume5
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNamePower
person.familyNameCanario
person.givenNameDeborah Mary
person.givenNameAdelino
person.identifier143624
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0003-1366-0246
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7101806760
person.identifier.scopus-author-id56568523700
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

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