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Stress, glucocorticoids and bone: A review from mammals and fish

2018-09Journal article Open access
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dc.contributor.authorSuarez-Bregua, Paula
dc.contributor.authorGuerreiro, Pedro M
dc.contributor.authorRotllant, Josep
dc.date.accessioned2018-12-07T14:58:10Z
dc.date.available2018-12-07T14:58:10Z
dc.date.issued2018-09
dc.description.abstractGlucocorticoids (GCs) are the final effector products of a neuroendocrine HPA/HPI axis governing energy balance and stress response in vertebrates. From a physiological point of view, basal GC levels are essential for intermediary metabolism and participate in the development and homeostasis of a wide range of body tissues, including the skeleton. Numerous mammalian studies have demonstrated that GC hormones exert a positive role during bone modeling and remodeling as they promote osteoblastogenesis to maintain the bone architecture. Although the pharmacological effect of the so-called stress hormones has been widely reported, the role of endogenous GCs on bone mineral metabolism as result of the endocrine stress response has been largely overlooked across vertebrates. In addition, stress responses are variable depending on the stressor (e.g., starvation, predation, and environmental change), life cycle events (e.g., migration and aging), and differ among vertebrate lineages, which react differently according to their biological, social and cognitive complexity (e.g., mineral demands, physical, and psychological stress). This review intends to summarize the endogenous GCs action on bone metabolism of mammals and fish under a variety of challenging circumstances. Particular emphasis will be given to the regulatory loop between GCs and the parathyroid hormone (PTH) family peptides, and other key regulators of mineral homeostasis and bone remodeling in vertebrates.
dc.description.sponsorshipSpanish Economy and Competitiveness Ministry projects [AGL2014-52473R, AGL2017-89648P]; Portuguese Foundation for Science and Technology [PTDC/BIA-ANM/4225/2012]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.3389/fendo.2018.00526
dc.identifier.issn1664-2392
dc.identifier.urihttp://hdl.handle.net/10400.1/11897
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media Sa
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHormone-related protein
dc.subjectBream Sparus-Aurata
dc.subjectHealthy elderly-men
dc.subjectWater rainbow-trout
dc.subjectMineral density
dc.subjectSpawning migration
dc.subjectOsteoblast differentiation
dc.subjectCalcium-transport
dc.subjectPlasma-cortisol
dc.subjectEndogenous glucocorticoids
dc.titleStress, glucocorticoids and bone: A review from mammals and fish
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-ANM%2F4225%2F2012/PT
oaire.citation.startPage526
oaire.citation.titleFrontiers in Endocrinology
oaire.citation.volume9
oaire.fundingStream3599-PPCDT
person.familyNameGuerreiro da Costa Guerreiro
person.givenNamePedro Miguel
person.identifierA-2539-2009
person.identifier.ciencia-id5C13-965D-3148
person.identifier.orcid0000-0001-5371-7919
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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