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Selective synthesis of 3-(1H-Tetrazol-5-yl)-indoles from 2H-Azirines and Arynes

2024-06-24Journal article Open access
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dc.contributor.authorGrosso, Carla
dc.contributor.authorAlves, Cláudia
dc.contributor.authorSase, Terver J.
dc.contributor.authorAlves, Nuno G.
dc.contributor.authorCardoso, Ana L.
dc.contributor.authorMelo, Teresa M. V. D. Pinho e
dc.contributor.authorLemos, Americo
dc.date.accessioned2024-07-22T10:50:40Z
dc.date.available2024-07-22T10:50:40Z
dc.date.issued2024-06-24
dc.description.abstractA new selective synthetic approach to indole derivatives bearing a tetrazole moiety has been developed. Arynes, generated in situ from o-(trimethylsilyl)aryl triflates and KF, reacted smoothly with 2-(2-benzyl-2H-tetrazol-5-yl)-2H-azirines to give 3-(2-benzyl-2H-tetrazol-5-yl)-indole derivatives with high selectivity. Deprotection of the tetrazole moiety gave 3-(1H-tetrazol-5-yl)-indole derivatives.eng
dc.description.sponsorshipPD/BD/143159/2019
dc.identifier.doi10.1021/acsomega.4c00305
dc.identifier.issn2470-1343
dc.identifier.urihttp://hdl.handle.net/10400.1/25686
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Chemical Society (ACS)
dc.relationCoimbra Chemistry Center
dc.relationCoimbra Chemistry Center
dc.relationSynthesis of Novel Indoles and Bisindolylmethanes: Approaches to Structures with Biological Activity
dc.relation.ispartofACS Omega
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAddition reactions
dc.subjectIndoles
dc.subjectMixtures
dc.subjectPrecursors
dc.subjectReaction products
dc.titleSelective synthesis of 3-(1H-Tetrazol-5-yl)-indoles from 2H-Azirines and Aryneseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCoimbra Chemistry Center
oaire.awardTitleCoimbra Chemistry Center
oaire.awardTitleSynthesis of Novel Indoles and Bisindolylmethanes: Approaches to Structures with Biological Activity
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00313%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00313%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F130198%2F2017/PT
oaire.citation.endPage29289
oaire.citation.issue27
oaire.citation.startPage29282
oaire.citation.titleAcs Omega
oaire.citation.volume9
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLemos
person.givenNameAmerico
person.identifier.ciencia-idA81D-6DC7-31E4
person.identifier.orcid0000-0001-9588-4555
person.identifier.ridB-4892-2008
person.identifier.scopus-author-id11139694000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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