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The preyssler-type polyoxotungstate exhibits anti-quorum sensing, antibiofilm, and antiviral activities

2022-06-30Journal article Open access
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dc.contributor.authorFaleiro, Maria Leonor
dc.contributor.authorMarques, Ana
dc.contributor.authorMartins, João
dc.contributor.authorJordão, Luísa
dc.contributor.authorNogueira, Isabel
dc.contributor.authorGumerova, Nadiia I.
dc.contributor.authorRompel, Annette
dc.contributor.authorAureliano, M.
dc.date.accessioned2022-07-26T08:54:41Z
dc.date.available2022-07-26T08:54:41Z
dc.date.issued2022-06-30
dc.date.updated2022-07-25T16:32:24Z
dc.description.abstractThe increase in bacterial resistance to antibiotics has led researchers to find new compounds or find combinations between different compounds with potential antibacterial action and with the ability to prevent the development of antibiotic resistance. Polyoxotungstates (POTs) are inorganic clusters that may fulfill that need, either individually or in combination with antibiotics. Herein, we report the ability of the polyoxotungstates (POTs) with Wells-Dawson P2W18, P2W17, P2W15, and Preyssler P5W30 type structures to differently affect Gram-negative and Gram-positive microorganisms, either susceptible or resistant to antibiotics. The compound P5W30 showed the highest activity against the majority of the tested bacterial strains in comparison with the other tested POTs (P2W15, P2W17 and P2W18) that did not show inhibition zones for the Gram-negative bacteria, A. baumanii I73775, E. coli DSM 1077, E. coli I73194, K. pneumoniae I7092374, and P. aeruginosa C46281). Generally, the results evidenced that Gram-positive bacteria are more susceptible to the POTs tested. The compound P5W30 was the one most active against S. aureus ATCC 6538 and MRSA16, reaching <0.83 mg·mL−1 (100 µM) and 4.96 mg·mL−1 (600 µM), respectively. Moreover, it was verified by NMR spectroscopy that the most promising POT, P5W30, remains intact under all the experimental conditions, after 24 h at 37 ◦C. This prompted us to further evaluate the anti-quorum sensing activity of P5W30 using the biosensor Chromobacterium violaceum CV026, as well as its antibiofilm activity both individually and in combination with the antibiotic cefoxitin against the methicillin-resistant Staphylococcus aureus 16 (MRSA16). P5W30 showed a synergistic antibacterial effect with the antibiotic cefoxitin and chloramphenicol against MRSA16. Moreover, the antibiofilm activity of P5W30 was more pronounced when used individually, in comparison with the combination with the antibioticcefoxitin. Finally, the antiviral activity of P5W30 was tested using the coliphage Qβ, showing a dosedependent response. The maximum inactivation was observed at 750 µM (6.23 mg·mL−1 ). In sum, P5W30 shows anti-quorum sensing and antibiofilm activities besides being a potent antibacterial agent against S. aureus and to exhibit antiviral activities against enteric viruses.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBiology 11 (7): 994 (2022)pt_PT
dc.identifier.doi10.3390/biology11070994pt_PT
dc.identifier.eissn2079-7737
dc.identifier.urihttp://hdl.handle.net/10400.1/18090
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntibacterial drugspt_PT
dc.subjectBacterial resistancept_PT
dc.subjectAntibiotic resistancept_PT
dc.subjectWells-Dawson polyoxometalatespt_PT
dc.subjectMultiresistantpt_PT
dc.subjectP5W30pt_PT
dc.subjectP2W18pt_PT
dc.titleThe preyssler-type polyoxotungstate exhibits anti-quorum sensing, antibiofilm, and antiviral activitiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.issue7pt_PT
oaire.citation.startPage994pt_PT
oaire.citation.titleBiologypt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFaleiro
person.familyNameAureliano
person.givenNameMaria Leonor
person.givenNameManuel
person.identifier252666
person.identifier584146
person.identifier.ciencia-id281D-5E01-F09A
person.identifier.ciencia-idAA14-3490-DC5E
person.identifier.orcid0000-0002-3878-6948
person.identifier.orcid0000-0003-4858-3201
person.identifier.ridI-3283-2012
person.identifier.scopus-author-id6507927018
person.identifier.scopus-author-id6603412860
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication5361e29a-3b79-4ce8-9f87-0c667d60588d
relation.isAuthorOfPublicationbb413661-7edd-4b57-8338-33889cfd05db
relation.isAuthorOfPublication.latestForDiscoverybb413661-7edd-4b57-8338-33889cfd05db
relation.isProjectOfPublicationfafa76a6-2cd2-4a6d-a3c9-772f34d3b91f
relation.isProjectOfPublication794d4c77-c731-471e-bc96-5a41dcd3d872
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