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Genomic characterisation of putative growth hormone releasing hormone (GHRH) receptor genes in the teleost fish Fugu rubripes

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dc.contributor.authorCardoso, João CR
dc.contributor.authorPower, Deborah
dc.contributor.authorElgar, Greg
dc.contributor.authorClark, M. S.
dc.date.accessioned2014-10-22T13:13:44Z
dc.date.available2014-10-22T13:13:44Z
dc.date.issued2003
dc.description.abstractThe genomic organisation of a putative GHRH receptor gene has been characterised in the teleost fish, Fugu rubripes. It comprises 13 exons and is at least 1.2 3 larger than previously described vertebrate GHRH receptors. Sequence conservation with other vertebrate GHRH receptors is highest over the seven transmembrane domains with preservation of 8 conserved cysteines and an N-glycosylation site in the N-terminal region, which are important for receptor activation. Database mining revealed a further putative GHRH receptor in Fugu, with phylogenetic tree topology indicating that this was potentially a teleost-specific duplication event. This is the first time that the genomic organisation of a GHRH receptor gene has been characterised from a nonmammalian vertebrate.por
dc.description.sponsorshipThis work was supported by an MRC grant to M.S.C and G.E and a FCT plurianual grant to CCMAR, Portugal. D.M.P was in receipt of a sabbatical grant (BLS58; FCT, Portugal). J.C.R.C was funded by FCT, Portugal (grant, BD/19925/99).por
dc.identifier.citationJoão C.R. Cardoso, Deborah M. Power, Greg Elgar, Melody S. Clark, "Genomic characterisation of putative growth hormone releasing hormone (GHRH) receptor genes in the teleost fish Fugu rubripes" in DNA Sequence, 2003 Vol. 14 (2), pp. 129–133.por
dc.identifier.doihttp://dx.doi.org/ 10.1080/1042517031000081142
dc.identifier.issn1042-5179
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5405
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherTaylor&Francispor
dc.subjectGrowth hormone releasing hormone (GHRH)por
dc.subjectFugu rubripespor
dc.subjectG-Protein Coupled Receptors (GPCRs)por
dc.titleGenomic characterisation of putative growth hormone releasing hormone (GHRH) receptor genes in the teleost fish Fugu rubripespor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage133por
oaire.citation.issue2por
oaire.citation.startPage129por
oaire.citation.titleDNA Sequencepor
oaire.citation.volume14por
person.familyNameCardoso
person.familyNamePower
person.givenNameJoão
person.givenNameDeborah Mary
person.identifier14332
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication1b670c84-15e3-4776-8871-50f9eb0eed0d
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

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