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Publicação
Genomic characterisation of putative growth hormone releasing hormone (GHRH) receptor genes in the teleost fish Fugu rubripes
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Orientador(es)
Resumo(s)
The genomic organisation of a putative GHRH receptor
gene has been characterised in the teleost fish, Fugu
rubripes. It comprises 13 exons and is at least 1.2 3 larger
than previously described vertebrate GHRH receptors.
Sequence conservation with other vertebrate GHRH
receptors is highest over the seven transmembrane
domains with preservation of 8 conserved cysteines and
an N-glycosylation site in the N-terminal region, which
are important for receptor activation. Database mining
revealed a further putative GHRH receptor in Fugu, with
phylogenetic tree topology indicating that this was
potentially a teleost-specific duplication event. This is
the first time that the genomic organisation of a GHRH
receptor gene has been characterised from a nonmammalian
vertebrate.
Descrição
Palavras-chave
Growth hormone releasing hormone (GHRH) Fugu rubripes G-Protein Coupled Receptors (GPCRs)
Contexto Educativo
Citação
João C.R. Cardoso, Deborah M. Power, Greg Elgar, Melody S. Clark, "Genomic characterisation of putative growth hormone releasing hormone (GHRH) receptor genes in the teleost fish Fugu rubripes" in DNA Sequence, 2003 Vol. 14 (2), pp. 129–133.
Editora
Taylor&Francis