Genomic characterisation of putative growth hormone releasing hormone (GHRH) receptor genes in the teleost fish Fugu rubripes

Cardoso, João CR; Power, Deborah; Elgar, Greg; Clark, M. S.

http://hdl.handle.net/10400.1/5405

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Abstract(s)

The genomic organisation of a putative GHRH receptor gene has been characterised in the teleost fish, Fugu rubripes. It comprises 13 exons and is at least 1.2 3 larger than previously described vertebrate GHRH receptors. Sequence conservation with other vertebrate GHRH receptors is highest over the seven transmembrane domains with preservation of 8 conserved cysteines and an N-glycosylation site in the N-terminal region, which are important for receptor activation. Database mining revealed a further putative GHRH receptor in Fugu, with phylogenetic tree topology indicating that this was potentially a teleost-specific duplication event. This is the first time that the genomic organisation of a GHRH receptor gene has been characterised from a nonmammalian vertebrate.

Keywords

Growth hormone releasing hormone (GHRH) Fugu rubripes G-Protein Coupled Receptors (GPCRs)

URI

http://hdl.handle.net/10400.1/5405

Citation

João C.R. Cardoso, Deborah M. Power, Greg Elgar, Melody S. Clark, "Genomic characterisation of putative growth hormone releasing hormone (GHRH) receptor genes in the teleost fish Fugu rubripes" in DNA Sequence, 2003 Vol. 14 (2), pp. 129–133.