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Nematode and Arthropod Genomes Provide New Insights into the Evolution of Class 2 B1 GPCRs

2014-03Journal article Open access
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dc.contributor.authorCardoso, João CR
dc.contributor.authorFélix, Rute C.
dc.contributor.authorPower, Deborah
dc.date.accessioned2014-10-23T09:15:26Z
dc.date.available2014-10-23T09:15:26Z
dc.date.issued2014-03
dc.description.abstractNematodes and arthropods are the most speciose animal groups and possess Class 2 B1 G-protein coupled receptors (GPCRs). Existing models of invertebrate Class 2 B1 GPCR evolution are mainly centered on Caenorhabditis elegans and Drosophila melanogaster and a few other nematode and arthropod representatives. The present study reevaluates the evolution of metazoan Class 2 B1 GPCRs and orthologues by exploring the receptors in several nematode and arthropod genomes and comparing them to the human receptors. Three novel receptor phylogenetic clusters were identified and designated cluster A, cluster B and PDF-R-related cluster. Clusters A and B were identified in several nematode and arthropod genomes but were absent from D. melanogaster and Culicidae genomes, whereas the majority of the members of the PDF-R-related cluster were from nematodes. Cluster A receptors were nematode and arthropod-specific but shared a conserved gene environment with human receptor loci. Cluster B members were orthologous to human GCGR, PTHR and Secretin members with which they probably shared a common origin. PDF-R and PDF-R related clusters were present in representatives of both nematodes and arthropods. The results of comparative analysis of GPCR evolution and diversity in protostomes confirm previous notions that C. elegans and D. melanogaster genomes are not good representatives of nematode and arthropod phyla. We hypothesize that at least four ancestral Class 2 B1 genes emerged early in the metazoan radiation, which after the protostome-deuterostome split underwent distinct selective pressures that resulted in duplication and deletion events that originated the current Class 2 B1 GPCRs in nematode and arthropod genomes.por
dc.description.sponsorshipThis work was supported by the Portuguese Foundation for Science and Technology (FCT) project PTDC/BIA-BCM/114395/2009, by the European Regional Development Fund through COMPETE and FCT under the project ‘‘PEst-C/MAR/LA0015/2011.’’ RCF is in receipt of an FCT grant (SFRH/BPD/89811/2012) and JCRC is supported by auxiliary research contract FCT Pluriannual funds attributed to CCMAR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.por
dc.identifier.citationCardoso JCR, Fe´ lix RC, Power DM (2014) Nematode and Arthropod Genomes Provide New Insights into the Evolution of Class 2 B1 GPCRs. PLoS ONE 9(3): e92220. doi:10.1371/journal.pone.0092220por
dc.identifier.doihttp://dx.doi.org/ 10.1371/journal.pone.0092220
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5417
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherPublic Library of Sciencepor
dc.subjectArthropodapor
dc.subjectCaenorhabditis eleganspor
dc.subjectChromosomespor
dc.subjectEvolutionary geneticspor
dc.titleNematode and Arthropod Genomes Provide New Insights into the Evolution of Class 2 B1 GPCRspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3por
oaire.citation.titlePlos Onepor
oaire.citation.volume9por
person.familyNameCardoso
person.familyNamePower
person.givenNameJoão
person.givenNameDeborah Mary
person.identifier14332
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id7101806760
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication1b670c84-15e3-4776-8871-50f9eb0eed0d
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscovery1b670c84-15e3-4776-8871-50f9eb0eed0d

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