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Comparative promoter analysis and its application to the identification of candidate regulatory factors of cartilage-expressed genes

2010Journal article Restricted access
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dc.contributor.authorConceição, N.
dc.contributor.authorCox, C. J.
dc.contributor.authorSimões, B.
dc.contributor.authorViegas, M.
dc.contributor.authorCancela, Leonor
dc.date.accessioned2014-10-27T10:41:19Z
dc.date.available2014-10-27T10:41:19Z
dc.date.issued2010
dc.date.updated2014-10-24T09:31:19Z
dc.description.abstractChondrocyte gene regulation is important for the generation and maintenance of cartilage tissues. Analysis of the transcriptional regulation of cartilage-specific genes, encoding both collagenous and noncollagenous proteins, provides a useful strategy to identify transcription factors (TFs) that control chondrocyte specification and differentiation. Our work aims at the identification of candidate TFs important for cartilage maintenance and development through an in silico approach. In order to better define the transcriptional regulatory networks that affect chondrogenesis in zebrafish we propose a combination of comparative promoter analysis and transcription factor binding site analysis using a TRANSFAC position weight matrix search to identify cis-regulatory transcription factor binding motifs in a set of cartilage characteristic genes. With this methodology we have successfully identified several transcription factors known to be important for chondrogenesis thus validating our in silico approach.por
dc.identifier.citationConceição, N.; Cox, C.J.; Simões, B.; Viegas, M.; Cancela, M.L.Comparative promoter analysis and its application to the identification of candidate regulatory factors of cartilage-expressed genes, Journal of Applied Ichthyology, 26, 2, 245-250, 2010.por
dc.identifier.doihttp://dx.doi.org/ 10.1111/j.1439-0426.2010.01415.x
dc.identifier.issn0175-8659
dc.identifier.otherAUT: LCA00739;
dc.identifier.urihttp://hdl.handle.net/10400.1/5517
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/j.1439-0426.2010.01415.x/abstractpor
dc.subjectCartilagepor
dc.subjectGenespor
dc.titleComparative promoter analysis and its application to the identification of candidate regulatory factors of cartilage-expressed genespor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage250por
oaire.citation.issue2por
oaire.citation.startPage245por
oaire.citation.titleJournal of Applied Ichthyologypor
oaire.citation.volume26por
person.familyNameCox
person.familyNameCancela
person.givenNameCymon
person.givenNameM. Leonor
person.identifier.ciencia-id6B15-9771-1D04
person.identifier.orcid0000-0002-4927-979X
person.identifier.orcid0000-0003-3114-6662
person.identifier.ridD-1303-2012
person.identifier.scopus-author-id7402112716
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication82c3689c-60b6-440d-9d7b-49e6dbd6861b
relation.isAuthorOfPublicationb9bbfe32-3dfe-4131-ad14-a4394008447f
relation.isAuthorOfPublication.latestForDiscoveryb9bbfe32-3dfe-4131-ad14-a4394008447f

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