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Resumo(s)
Introdução: A obesidade é uma doença crónica caracterizada pela acumulação anormal de gordura corporal, ocorrendo um desequilíbrio entre as calorias que são ingeridas e as que são gastas. A obesidade pode contribuir para o desenvolvimento de várias outras patologias, entre as quais o cancro da mama. Embora existam vários fármacos que podem ser utilizados para o tratamento da obesidade, o tratamento que tem demonstrado ser mais eficaz a longo prazo é a cirurgia bariátrica. Para além da perda de peso, o tratamento cirúrgico demonstrou melhorar vários dos problemas de saúde associados à obesidade. Objetivo: Compreender a influência que a cirurgia bariátrica tem no risco do desenvolvimento de cancro da mama. Métodos: Foi realizada uma pesquisa de revisões sistemáticas nas bases de dados PubMed e Web of Science, com o objetivo de avaliar a relação entre a cirurgia bariátrica e a incidência de cancro da mama. Foram considerados como critérios de inclusão os artigos serem revisões sistemáticas e/ou meta-análises e relacionarem a realização de cirurgia bariátrica com o cancro da mama. Foram excluídos artigos que reportem estudos originais ou ensaios clínicos, ou outros artigos que não são revisões sistemáticas e/ou meta-análises, artigos que refiram apenas outras cirurgias, e artigos que refiram outros cancros, mas não incluem o cancro da mama. Resultados: Após seleção, foram analisados 6 artigos que relacionam a cirurgia bariátrica com o risco de desenvolvimento de cancro da mama. Os resultados analisados indicam que houve uma redução de 44% a 51% na redução do risco de desenvolvimento de cancro da mama após o tratamento cirúrgico da obesidade. Conclusão: Com esta revisão do tipo umbrella, conclui-se que os pacientes com obesidade, depois de submetidos a cirurgia bariátrica, apresentam um menor risco de desenvolvimento de cancro da mama em relação aos pacientes que não fizeram a cirurgia.
Introduction: Obesity is a chronic disease characterized by the abnormal accumulation of body fat, resulting from an imbalance between caloric intake and energy expenditure. Obesity can lead to the development of several comorbidities, including breast cancer. Although there are various drugs that can be used to treat this condition, bariatric surgery has demonstrated superior long-term efficacy. In addition to promoting weight loss, surgical intervention has been shown to improve multiple obesity-related health conditions. Objective: To evaluate the impact of bariatric surgery on the risk of developing breast cancer. Methods: A systematic literature search was conducted in the PubMed and Web of Science databases to identify systematic reviews and/or meta-analyses examining the association between bariatric surgery and breast cancer incidence. Inclusion criteria required that studies be systematic reviews and/or meta-analyses that specifically addressed the relationship between bariatric surgery and breast cancer. Exclusion criteria included original research articles, clinical trials, non-systematic reviews, reviews focusing exclusively on other surgical procedures, or studies addressing cancers other than breast cancer. Results: After the selection process, six articles were analyzed that examined the association between bariatric surgery and the risk of developing breast cancer. The findings consistently indicated a reduction in breast cancer risk ranging from 44% to 51% following bariatric surgery in individuals with obesity. Conclusion: This umbrella review concludes that patients with obesity who undergo bariatric surgery have a lower risk of developing breast cancer compared to those who do not undergo the surgery.
Introduction: Obesity is a chronic disease characterized by the abnormal accumulation of body fat, resulting from an imbalance between caloric intake and energy expenditure. Obesity can lead to the development of several comorbidities, including breast cancer. Although there are various drugs that can be used to treat this condition, bariatric surgery has demonstrated superior long-term efficacy. In addition to promoting weight loss, surgical intervention has been shown to improve multiple obesity-related health conditions. Objective: To evaluate the impact of bariatric surgery on the risk of developing breast cancer. Methods: A systematic literature search was conducted in the PubMed and Web of Science databases to identify systematic reviews and/or meta-analyses examining the association between bariatric surgery and breast cancer incidence. Inclusion criteria required that studies be systematic reviews and/or meta-analyses that specifically addressed the relationship between bariatric surgery and breast cancer. Exclusion criteria included original research articles, clinical trials, non-systematic reviews, reviews focusing exclusively on other surgical procedures, or studies addressing cancers other than breast cancer. Results: After the selection process, six articles were analyzed that examined the association between bariatric surgery and the risk of developing breast cancer. The findings consistently indicated a reduction in breast cancer risk ranging from 44% to 51% following bariatric surgery in individuals with obesity. Conclusion: This umbrella review concludes that patients with obesity who undergo bariatric surgery have a lower risk of developing breast cancer compared to those who do not undergo the surgery.
Descrição
Palavras-chave
Cancro da mama Cirurgia bariátrica Obesidade Redução do risco Tratamento