Repository logo
 
Publication

Comparative eye and liver differentially expressed genes reveal monochromatic vision and cancer resistance in the shortfin mako shark (Isurus oxyrinchus)

2020-11Journal article Open access
Simple item page
dc.contributor.authorDomingues, Rodrigo R.
dc.contributor.authorMastrochirico-Filho, Vito Antonio
dc.contributor.authorMendes, Natalia J.
dc.contributor.authorHashimoto, Diogo T.
dc.contributor.authorCoelho, Rui
dc.contributor.authorda Cruz, Vanessa Paes
dc.contributor.authorAntunes, Agostinho
dc.contributor.authorForesti, Fausto
dc.contributor.authorMendonca, Fernando F.
dc.date.accessioned2021-06-18T16:25:48Z
dc.date.available2021-06-18T16:25:48Z
dc.date.issued2020-11
dc.description.abstractThe shortfin mako, Isurus oxyrinchus is an oceanic pelagic shark found worldwide in tropical and subtropical waters. However, the understanding of its biology at molecular level is still incipient. We sequenced the messenger RNA isolated from eye and liver tissues. De novo transcriptome yielded a total of 705,940 transcripts. A total of 3774 genes were differentially expressed (DEGs), with 1612 in the eye and 2162 in the liver. Most DEGs in the eye were related to structural and signaling functions, including nonocular and ocular opsin genes, whereas nine out of ten most overexpressed genes in the liver were related to tumor suppression, wound healing, and human diseases. Furthermore, DEGs findings provide insights on the monochromatic shark vision and a repertory of cancer-related genes, which may be insightful to elucidate shark resistance to cancer. Therefore, our results provide valuable sequence resources for future functional and population studies.
dc.description.sponsorshipFundação de Amparo a Pesquisa do Estado de Sao Paulo (Brasil) (FAPESP) [FAPESP 2014/19740-7]
dc.description.sponsorshipFundacao para a Ciencia e Tecnologia (FCT, Portugal) Portuguese Foundation for Science and Technology
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [FAPESP 2017/02420-8, 2018/21319-9]
dc.description.sponsorshipFCT Portuguese Foundation for Science and Technology European Commission [UID/Multi/04423/2019, PTDC/CTA-AMB/31774/2017, POCI-01-0145-FEDER/031774/2017]
dc.description.sponsorshipEuropean Regional Development Fund -program PT2020
dc.description.sponsorshipEuropean Structural and Investment Funds Competitiveness and Internationalization Operational ProgramCOMPETE 2020
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.ygeno.2020.08.037
dc.identifier.issn0888-7543
dc.identifier.urihttp://hdl.handle.net/10400.1/15677
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectElasmobranch
dc.subjectGene ontology
dc.subjectPhotoreception
dc.subjectTranscriptomics
dc.subjectTumor suppression
dc.subject.otherBiotechnology & Applied Microbiology
dc.subject.otherGenetics & Heredity
dc.titleComparative eye and liver differentially expressed genes reveal monochromatic vision and cancer resistance in the shortfin mako shark (Isurus oxyrinchus)
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4826
oaire.citation.issue6
oaire.citation.startPage4817
oaire.citation.titleGenomics
oaire.citation.volume112
person.familyNameCoelho
person.givenNameRui
person.identifier134638
person.identifier.ciencia-idDC1A-20B7-EAC0
person.identifier.orcid0000-0003-3813-5157
person.identifier.ridC-1163-2008
person.identifier.scopus-author-id56257111100
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication6366aa1b-1301-43a3-b2b0-1280311ac95f
relation.isAuthorOfPublication.latestForDiscovery6366aa1b-1301-43a3-b2b0-1280311ac95f

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Domingues_2020_Eye-liver_expressed-genes-shortfin-mako_PostPrint.pdf
Size:
385.57 KB
Format:
Adobe Portable Document Format
Download

Collections

CCM2-Artigos (em revistas ou actas indexadas)