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Effects of vitamin D supplementation on bone health and bone-related parameters in HIV-infected patients: A systematic review and meta-analysis

2022-02Journal article Restricted access
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dc.contributor.authorRezamand, Gholamreza
dc.contributor.authorEstêvão, M. Dulce
dc.contributor.authorMorvaridzadeh, Mojgan
dc.contributor.authorAkbari, Abolfazl
dc.contributor.authorTabaeian, Seidamir Pasha
dc.contributor.authorPizarro, Ana Beatriz
dc.contributor.authorMalekahmadi, Mahsa
dc.contributor.authorHasani, Motahareh
dc.contributor.authorRoffey, Darren M.
dc.contributor.authorMirzaei, Alireza
dc.contributor.authorHeshmati, Javad
dc.date.accessioned2022-12-12T11:21:07Z
dc.date.available2022-12-12T11:21:07Z
dc.date.issued2022-02
dc.description.abstractPurpose: There is growing evidence that bone health is decreased in individuals with HIV infection. Vitamin D deficiency is also highly prevalent among HIV-infected patients. The literature was systematically reviewed to determine whether bone health and bone-related parameters may improve with vitamin D supplementation in HIV-infected individuals. Methods: Four databases were systematically searched for randomized clinical trials of vitamin D supplementation in HIV infection, published from January 1990 to September 2021. No language or publication restrictions were applied. Standardized mean differences (SMD) with 95% CIs are reported. A random-effects model was used to perform meta-analysis. Findings: Ten studies met the inclusion criteria (N = 733 participants at study completion). The mean ages of the patients in the included trials ranged from 10 to 49 years. The meta-analysis indicated that with vitamin D supplementation, serum 25-hydroxy vitamin D (25[OH]D) level was significantly increased (SMD, 1.86; 95% CI, 1.02 to 2.70; I-2 = 94.4%), but there were no significant effects on levels of serum 1,25-dihydroxy vitamin D (1,25-[OH](2)D) (SMD, 0.29; 95% CI, -0.07 to 0.64; I-2 = 67.4%), total bone mineral density (SMD, 0.07; 95% CI, -0.23 to 0.37; I-2 = 00.0%), spine bone mineral density (SMD, 0.15; 95% CI, -0.19 to 0.49; I-2 = 17.3%), and parathyroid hormone level (SMD, -0.18; 95% CI, -0.37 to 0.02; I-2 = 1.2%) in HIV-infected patients. (C) 2022 Elsevier Inc.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.clinthera.2021.12.012pt_PT
dc.identifier.eissn1879-114X
dc.identifier.urihttp://hdl.handle.net/10400.1/18620
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectBone mineral densitypt_PT
dc.subjectHIVpt_PT
dc.subjectParathyroid hormonept_PT
dc.subjectVitamin Dpt_PT
dc.titleEffects of vitamin D supplementation on bone health and bone-related parameters in HIV-infected patients: A systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage25.e8pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPagee11pt_PT
oaire.citation.titleClinical Therapeuticspt_PT
oaire.citation.volume44pt_PT
person.familyNameEstêvão
person.givenNameMaria Dulce da Mota Antunes de Oliveira
person.identifierI-4695-2014
person.identifier.ciencia-id881B-53E8-0DB1
person.identifier.orcid0000-0002-7151-8363
person.identifier.scopus-author-id8381590400
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67887883-2695-48cc-8221-aa46780ac143
relation.isAuthorOfPublication.latestForDiscovery67887883-2695-48cc-8221-aa46780ac143

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