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Chemical characterization, cytotoxic, antioxidant, antimicrobial, and enzyme inhibitory effects of different extracts from one sage (Salvia ceratophylla L.) from Turkey: open a new window on industrial purposes

2021Journal article Open access
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dc.contributor.authorUysal, Sengul
dc.contributor.authorZengin, Gokhan
dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorAk, Gunes
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorUysal, Ahmet
dc.contributor.authorSadeer, Nabeelah Bibi
dc.contributor.authorJekő, József
dc.contributor.authorCziáky, Zoltán
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorYıldıztugay, Evren
dc.contributor.authorElbasan, Fevzi
dc.contributor.authorCustódio, Luísa
dc.date.accessioned2021-03-16T15:09:44Z
dc.date.available2021-03-16T15:09:44Z
dc.date.issued2021
dc.description.abstractIn the present study, the methanolic, hydro-methanolic, dichloromethane, hexane and aqueous extracts of Salvia ceratophylla L. (Family: Lamiaceae), a lemon-scented herb, were tested for total phenolic (TPC) and flavonoid content (TFC) and antioxidant activities were evaluated using a battery of assays (2,2-diphenyl-1- picrylhydrazyl (DPPH), 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity, total antioxidant capacity (TAC) (phosphomolybdenum) and metal chelating). Enzyme inhibitory effects were investigated using acetyl- (AChE), butyryl-cholinesterase (BChE), tyrosinase, a-amylase and a-glucosidase as target enzymes. Regarding the cytotoxic abilities, HepG2, B164A5 and S17 cell lines were used. The phytochemical profile was conducted using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). Our data showed that the methanolic aerial extracts possessed the highest phenolic (72.50 0.63 mg gallic acid equivalent per g) and flavonoid (43.77 1.09 mg rutin equivalent per g) contents. The hydromethanolic aerial extract showed significant DPPH radical scavenging activity (193.40 0.27 mg TE per g) and the highest reducing potential against CUPRAC (377.93 2.38 mg TE per g). The best tyrosinase activity was observed with dichloromethane root extract (125.45 1.41 mg kojic acid equivalent per g). Among the tested extracts, hexane root extract exerted the highest antimicrobial potential with a minimum inhibitory concentration value of 0.048 mg mL 1. Methanolic root extract showed the lowest cytotoxicity (28%) against HepG2 cells. Phytochemical analysis revealed the presence of important polyphenolic compounds including luteolin, gallic acid, rosmarinic acid, to name a few. This research can be used as one methodological starting point for further investigations on this lemon-scented herb.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1039/D0RA10044Gpt_PT
dc.identifier.issn2046-2069
dc.identifier.urihttp://hdl.handle.net/10400.1/15234
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleChemical characterization, cytotoxic, antioxidant, antimicrobial, and enzyme inhibitory effects of different extracts from one sage (Salvia ceratophylla L.) from Turkey: open a new window on industrial purposespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage5310pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage5295pt_PT
oaire.citation.titleRSC Advancespt_PT
oaire.citation.volume11pt_PT
person.familyNameRodrigues
person.familyNameCustódio
person.givenNameMaria João
person.givenNameLuísa
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscoveryf9cfed0f-6b67-413e-988c-ac7397183471

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