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Non-steroidal anti-inflammatory drug (NSAID) ibuprofen distresses antioxidant defense system in mussel Mytilus galloprovincialis gills

2011Journal article Restricted access
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dc.contributor.authorGonzalez-Rey, Maria
dc.contributor.authorBebianno, Maria JoĂŁo
dc.date.accessioned2020-04-27T20:25:36Z
dc.date.available2020-04-27T20:25:36Z
dc.date.issued2011
dc.description.abstractActive pharmaceutical ingredients (APIs) are presently considered an emergent class of environmental contaminants. Ibuprofen (IBU) is one of the most applied non-steroidal anti-inflammatory drugs (NSAIDs) in the world. Several authors report the occurrence of IBU in influents and effluents of waste water treatment plants (WWTPs), surface, river and public tap water in numerous countries. However, very little is known about the risks and chronic effects of IBU exposure in non-target organisms. This approach undertakes the assessment of several oxidative stress biomarkers responses through the analysis of antioxidant enzymes activities (superoxide dismutase - SOD, catalase - CAT, glutathione S-transferase - GST, glutathione reductase - GR) and lipid peroxidation (LPO) levels in sentinel species mussel Mytilus galloprovincialis gills exposed for 2 weeks to an environmental realistic concentration of IBU. Results clearly show the significant induction and positive correlation between SOD activity and LPO in exposed gills, concomitant to an antioxidant defense depletion of CAT, GR and GST compared to controls. The integration of all biomarkers in mussels' gills separates non- and exposed groups supporting the breakdown of the redox defense system and IBU's pro-oxidant action. Further studies are needed to test possible endocrine disruption effects in mussels' reproduction fitness as IBU is involved on prostaglandins biosynthesis inhibition.pt_PT
dc.description.sponsorshipsubprojects Endocrinobiotox and Farmacotox of POCTEP-0042-RISE-5-E projectpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1016/j.aquatox.2011.06.015pt_PT
dc.identifier.issn0166-445X
dc.identifier.urihttp://hdl.handle.net/10400.1/13792
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEFFECTS OF ACTIVE PHARMACEUTICAL RESIDUES IN MYTILUS GALLOPROVINCIALIS
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0166445X11001846?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnti-inflammatory agentspt_PT
dc.subjectAntioxidantspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectCatalasept_PT
dc.subjectGillspt_PT
dc.subjectGlutathione reductasept_PT
dc.subjectGlutathione transferasept_PT
dc.subjectIbuprofenpt_PT
dc.subjectLipid peroxidationpt_PT
dc.subjectMytiluspt_PT
dc.subjectPrincipal component analysispt_PT
dc.subjectSuperoxide dismutasept_PT
dc.subjectNon-steroidalpt_PT
dc.subjectOxidative Stresspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectMusselpt_PT
dc.subjectAntioxidant enzymespt_PT
dc.subjectLipid peroxidationpt_PT
dc.titleNon-steroidal anti-inflammatory drug (NSAID) ibuprofen distresses antioxidant defense system in mussel Mytilus galloprovincialis gillspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEFFECTS OF ACTIVE PHARMACEUTICAL RESIDUES IN MYTILUS GALLOPROVINCIALIS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F41606%2F2007/PT
oaire.citation.endPage269pt_PT
oaire.citation.issue3-4pt_PT
oaire.citation.startPage264pt_PT
oaire.citation.titleAquatic Toxicologypt_PT
oaire.citation.volume105pt_PT
person.familyNameGonzalez-Rey
person.familyNameBebianno
person.givenNameMaria
person.givenNameMaria
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0002-9343-8460
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a CiĂȘncia e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery182cc3b5-3e8d-4baf-9220-638978bef660
relation.isProjectOfPublication8d64e32a-8e7e-4fd4-916c-5ab0994ec922
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