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The interplay between mineral metabolism, vascular calcification and inflammation in Chronic Kidney Disease (CKD): challenging old concepts with new facts

2019Journal article Open access
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dc.contributor.authorViegas, Carla
dc.contributor.authorAraujo, Nuna C. P.
dc.contributor.authorMarreiros, Catarina
dc.contributor.authorSimes, Dina
dc.date.accessioned2020-07-27T14:50:44Z
dc.date.available2020-07-27T14:50:44Z
dc.date.issued2019
dc.description.abstractChronic kidney disease (CKD) is one of the most powerful predictors of premature cardiovascular disease (CVD), with heightened susceptibility to vascular intimal and medial calcification associated with a high cardiovascular mortality. Abnormal mineral metabolism of calcium (Ca) and phosphate (P) and underlying (dys)regulated hormonal control in CKD-mineral and bone disorder (MBD) is often accompanied by bone loss and increased vascular calcification (VC). While VC is known to be a multifactorial process and a major risk factor for CVD, the view of primary triggers and molecular mechanisms complexity has been shifting with novel scientific knowledge over the last years. In this review we highlight the importance of calcium-phosphate (CaP) mineral crystals in VC with an integrated view over the complexity of CKD, while discuss past and recent literature aiming to highlight novel horizons on this major health burden. Exacerbated VC in CKD patients might result from several interconnected mechanisms involving abnormal mineral metabolism, dysregulation of endogenous calcification inhibitors and inflammatory pathways, which function in a feedback loop driving disease progression and cardiovascular outcomes. We propose that novel approaches targeting simultaneously VC and inflammation might represent valuable new prognostic tools and targets for therapeutics and management of cardiovascular risk in the CKD population.pt_PT
dc.description.sponsorshipPortuguese Foundation for Science and Technology (UID/Multi/04326/2019); Portuguese Society of Nephrology (SPN)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.18632/aging.102046pt_PT
dc.identifier.issn1945-4589
dc.identifier.urihttp://hdl.handle.net/10400.1/14525
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherImpact Journalspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectChronic kidney diseasept_PT
dc.subjectCardiovascular diseasept_PT
dc.subjectVascular calcification and inflammationpt_PT
dc.subjectVitamin K-dependent proteinspt_PT
dc.subjectCalciprotein particlespt_PT
dc.subjectExtracellular vesiclespt_PT
dc.titleThe interplay between mineral metabolism, vascular calcification and inflammation in Chronic Kidney Disease (CKD): challenging old concepts with new factspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4299pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage4274pt_PT
oaire.citation.titleAgingpt_PT
oaire.citation.volume11pt_PT
person.familyNameViegas
person.familyNameAraujo
person.familyNameMARREIROS
person.familyNameSimes
person.givenNameCarla
person.givenNameNuna
person.givenNameCATARINA
person.givenNameDina
person.identifier.ciencia-idC414-F596-EEC6
person.identifier.ciencia-idB116-E70E-EB2A
person.identifier.orcid0000-0002-5765-3665
person.identifier.orcid0000-0002-7602-0150
person.identifier.orcid0000-0002-5145-4753
person.identifier.ridN-6695-2014
person.identifier.ridN-8531-2013
person.identifier.ridN-2789-2014
person.identifier.scopus-author-id8656310300
person.identifier.scopus-author-id7201884723
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication3423e71b-934d-4da7-9c81-4e56c7930252
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relation.isAuthorOfPublication31bac96d-1d01-4b8f-8f2b-9da4be31ea41
relation.isAuthorOfPublication.latestForDiscoveryfcb4a0e0-0a88-4582-946e-eda31694c02c

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