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Biodegradation of paracetamol by some gram-positive bacterial isolates

2021Journal article Restricted access
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dc.contributor.authorDa Luz Palma, Tânia Cristina
dc.contributor.authorMagno, Gustavo
dc.contributor.authorCosta, Maria Clara
dc.date.accessioned2021-06-22T08:29:56Z
dc.date.available2021-06-22T08:29:56Z
dc.date.issued2021
dc.description.abstractBacterial isolates with the capacity to remove paracetamol were selected from an activated sludge sample collected in an oxidation ditch of a wastewater treatment plant. Among these, twelve bacterial isolates were selected according to their capacity to grow in the presence of paracetamol. They were identified using the colony morphotype procedure and by 16S rRNA gene sequencing analysis, but only four of them showed the ability to utilise paracetamol as the sole carbon source in the presence of a nitrogen supply. Those four bacterial isolates were assigned to species of the genera Bacillus, [Brevibacterium], Corynebacterium and Enterococcus. Bacterial isolates were cultured in liquid mineral salt medium (MSM) spiked with 200 mg/L of paracetamol at 28 °C in the dark. In cultures inoculated with [Brevibacterium] frigoritolerans, Corynebacterium nuruki and Enterococcus faecium, removal of 97 ± 4%, 97 ± 6% and 86.9 ± 0.8% of paracetamol at 200 mg/L were obtained, respectively, while in the presence of a species belonging to Bacillus cereus group removal of the drug below the limits of detection was attained with evidence of mineralisation, after 144 h of incubation. During the degradation process, the metabolites 4-aminophenol, hydroquinone and 2-hexenoic acid were detected. As far as we know, these species are herein first-time described as paracetamol degraders.pt_PT
dc.description.sponsorshipFCT: UIDB/04326/2020; European Comission:0483_PROBIOMA_5_Ept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s00284-021-02543-4pt_PT
dc.identifier.issn0343-8651
dc.identifier.urihttp://hdl.handle.net/10400.1/16332
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationBiodegradation of widely used pharmaceutical compounds by bacterial communities
dc.titleBiodegradation of paracetamol by some gram-positive bacterial isolatespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBiodegradation of widely used pharmaceutical compounds by bacterial communities
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F95075%2F2013/PT
oaire.citation.endPage2786pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage2774pt_PT
oaire.citation.titleCurrent Microbiologypt_PT
oaire.citation.volume78pt_PT
person.familyNameDa Luz Palma
person.familyNameCosta
person.givenNameTânia Cristina
person.givenNameMaria Clara
person.identifier.ciencia-id0614-DE1E-9632
person.identifier.ciencia-id7110-A28E-3C8A
person.identifier.orcid0000-0001-8614-570X
person.identifier.orcid0000-0003-1340-5237
person.identifier.ridM-6189-2013
person.identifier.scopus-author-id35354952400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication11c29f10-6e2b-40d8-9c74-2cc45be6d7a7
relation.isAuthorOfPublication.latestForDiscovery11c29f10-6e2b-40d8-9c74-2cc45be6d7a7
relation.isProjectOfPublicationc3ca4a85-a07e-4b48-934e-04c63a8d268f
relation.isProjectOfPublication.latestForDiscoveryc3ca4a85-a07e-4b48-934e-04c63a8d268f

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